Isolation and characterization of protective cytolytic T cells in a rodent malaria model system
Détails
ID Serval
serval:BIB_CEA1B3FF4CC9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Isolation and characterization of protective cytolytic T cells in a rodent malaria model system
Périodique
Immunology Letters
ISSN
0165-2478 (Print)
Statut éditorial
Publié
Date de publication
08/1990
Volume
25
Numéro
1-3
Pages
27-31
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Aug
Résumé
Protective immunity against malaria is induced by immunization with irradiation-attenuated sporozoites. Here we report the isolation of cytolytic T-cell (CTL) clones from BALB/c (H-2d) mice immunized with either Plasmodium berghei or Plasmodium yoelii sporozoites. The epitopes recognized by these CTL can be mimicked by synthetic peptides corresponding to a homologous region in the CS proteins of both rodent malaria species. Both peptides are recognized by the CTL in the context of the same MHC class I molecule, H-2 Kd. In vivo adoptive transfer of the CTL clones into non-immune syngeneic mice protected them from a lethal challenge of infectious sporozoites.
Mots-clé
Amino Acid Sequence
Animals
Antigens, Protozoan/immunology
Cell Separation
Clone Cells
Disease Models, Animal
Epitopes/immunology
Immunotherapy, Adoptive
Malaria/*immunology
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Peptide Fragments/chemical synthesis/immunology
Plasmodium berghei/immunology
Plasmodium yoelii/*immunology
*Protozoan Proteins
Spleen/cytology
T-Lymphocytes, Cytotoxic/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 11:28
Dernière modification de la notice
20/08/2019 15:49