BACKGROUND: Rhegmatogenous retinal detachment associated with intraocular tumors has been described in a small number of cases. We describe a patient with choroidal melanoma associated with a rhegmatogenous retinal detachment and a macular hole. METHODS: A 71-year-old man underwent enucleation for a bulky pigmented tumor overying the macula. RESULTS: Hystopathological examination revealed moderate cystoid macular edema with a full-thickness macular hole and a mixed-cell type choroidal melanoma. CONCLUSIONS: The relationships between choroidal melanoma, macular hole and rhegmatogenous retinal detachment are discussed.