Mechanisms of cross-modal plasticity in early-blind subjects.

Détails

ID Serval
serval:BIB_CE20DA1090AD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Mechanisms of cross-modal plasticity in early-blind subjects.
Périodique
Journal of Neurophysiology
Auteur(s)
Lewis L.B., Saenz M., Fine I.
ISSN
1522-1598[electronic], 0022-3077[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
104
Numéro
6
Pages
2995-3008
Langue
anglais
Résumé
A variety of studies have demonstrated enhanced blood oxygenation level dependent responses to auditory and tactile stimuli within occipital cortex as a result of early blindness. However, little is known about the organizational principles that drive this cross-modal plasticity. We compared BOLD responses to a wide variety of auditory and tactile tasks (vs. rest) in early-blind and sighted subjects. As expected, cross-modal responses were larger in blind than in sighted subjects in occipital cortex for all tasks (cross-modal plasticity). Within both blind and sighted subject groups, we found patterns of cross-modal activity that were remarkably similar across tasks: a large proportion of cross-modal responses within occipital cortex are neither task nor stimulus specific. We next examined the mechanisms underlying enhanced BOLD responses within early-blind subjects. We found that the enhancement of cross-modal responses due to early blindness was best described as an additive shift, suggesting that cross-modal plasticity within blind subjects does not originate from either a scaling or unmasking of cross-modal responsivities found in sighted subjects.
Pubmed
Web of science
Création de la notice
04/02/2011 15:49
Dernière modification de la notice
20/08/2019 16:48
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