Protective role of early aquaporin 4 induction against postischemic edema formation.

Détails

ID Serval
serval:BIB_CE092B57EB2D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Protective role of early aquaporin 4 induction against postischemic edema formation.
Périodique
Journal of cerebral blood flow and metabolism
Auteur(s)
Hirt L., Ternon B., Price M., Mastour N., Brunet J.F., Badaut J.
ISSN
1559-7016[electronic]
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
29
Numéro
2
Pages
423-433
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Aquaporin 4 (AQP4) is a water channel involved in water movements across the cell membrane and is spatially organized on the cell surface in orthogonal array particles (OAPs). Its role in edema formation or resolution after stroke onset has been studied mainly at late time points. We have shown recently that its expression is rapidly induced after ischemia coinciding in time with an early swelling of the ischemic hemisphere. There are two isoforms of AQP4: AQP4-M1 and AQP4-M23. The ratio of these isoforms influences the size of the OAPs but the functional impact is not known. The role of the early induction of AQP4 is not yet known. Thrombin preconditioning in mice provides a useful model to study endogenous protective mechanisms. Using this model, we provide evidence for the first time that the early induction of AQP4 may contribute to limit the formation of edema and that the AQP4-M1 isoform is predominantly induced in the ischemic tissue at this time point. Although it prevents edema formation, the early induction of the AQP4 expression does not prevent the blood-brain barrier disruption, suggesting an effect limited to the prevention of edema formation possibly by removing of water from the tissue.
Mots-clé
Animals, Aquaporin 4/genetics, Aquaporin 4/metabolism, Blood-Brain Barrier, Brain Ischemia/metabolism, Disease Models, Animal, Edema/metabolism, Edema/pathology, Gene Expression Regulation, Male, Mice, Protein Isoforms/genetics, Protein Isoforms/metabolism, Stroke/metabolism, Thrombin/metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/02/2009 14:53
Dernière modification de la notice
20/08/2019 16:48
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