Analysis of risk factors for long-term glaucomatous damage development.

Détails

ID Serval
serval:BIB_CDBBCA7A9A5D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Analysis of risk factors for long-term glaucomatous damage development.
Périodique
Klinische Monatsblatter fur Augenheilkunde
Auteur(s)
Gross S., Gugleta K., Turksever C., Ledolter A., Kochkorov A., Flammer J., Orgul S.
ISSN
1439-3999 (Electronic)
ISSN-L
0023-2165
Statut éditorial
Publié
Date de publication
04/2014
Peer-reviewed
Oui
Volume
231
Numéro
4
Pages
335-339
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The aim of this study was to analyze predictors of long-term glaucoma progression.
We followed 17 primary open angle glaucoma patients (POAG) and 25 ocular hypertensives (OHT) over three years, with regular follow-up examinations of both eyes every 6 months. Glaucoma damage was quantified by optical coherence tomography (retinal nerve fiber layer - OCT RNFL) and by perimetry. Corneal and hand temperature (infrared thermometer), corneal hysteresis, pachymetry and ocular pulse amplitude (OPA) readings were taken at baseline, and applanatory intraocular pressure and retinal vessel analysis recordings were made at baseline and follow-up visits. Forward-stepwise multiple regression analysis was performed.
With OCT-RNFL progression as the dependent variable, the model selected initial diagnosis (OHT less probable of progressing), baseline RNFL thickness, retinal arterial and venous diameter and arterial flicker response as significant damage predictors. For visual field damage progression, these were: corneal temperature, OPA, initial diagnosis and venous flicker response (all p<0.05).
Initial damage and vascular factors are strong predictors of future glaucoma progression.

Mots-clé
Female, Glaucoma, Open-Angle/complications, Glaucoma, Open-Angle/pathology, Humans, Longitudinal Studies, Male, Middle Aged, Retina/pathology, Retinal Diseases/etiology, Retinal Diseases/pathology, Risk Factors, Switzerland, Vision Disorders/etiology, Vision Disorders/pathology
Pubmed
Web of science
Création de la notice
22/01/2018 10:12
Dernière modification de la notice
20/08/2019 16:48
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