Serum calcification propensity is independently associated with disease activity in systemic lupus erythematosus.

Détails

Ressource 1Télécharger: 29364894_BIB_CDB924CD0726.pdf (1495.59 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_CDB924CD0726
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Serum calcification propensity is independently associated with disease activity in systemic lupus erythematosus.
Périodique
PloS one
Auteur⸱e⸱s
Dahdal S., Devetzis V., Chalikias G., Tziakas D., Chizzolini C., Ribi C., Trendelenburg M., Eisenberger U., Hauser T., Pasch A., Huynh-Do U., Arampatzis S.
Collaborateur⸱rice⸱s
Swiss Systemic Lupus Erythematosus Cohort Study Group
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2018
Peer-reviewed
Oui
Volume
13
Numéro
1
Pages
e0188695
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Systemic lupus erythematosus (SLE) is associated with severe cardiovascular complications. The T50 score is a novel functional blood test quantifying calcification propensity in serum. High calcification propensity (or low T50) is a strong and independent determinant of all-cause mortality in various patient populations.
A total of 168 patients with ≥ 4 American College of Rheumatology (ACR) diagnostic criteria from the Swiss Systemic lupus erythematosus Cohort Study (SSCS) were included in this analysis. Serum calcification propensity was assessed using time-resolved nephelometry.
The cohort mainly consisted of female (85%), middle-aged (43±14 years) Caucasians (77%). The major determinants of T50 levels included hemoglobin, serum creatinine and serum protein levels explaining 43% of the variation at baseline. Integrating disease activity (SELENA-SLEDAI) into this multivariate model revealed a significant association between disease activity and T50 levels. In a subgroup analysis considering only patients with active disease (SELENA-SLEDAI score ≥4) we found a negative association between T50 and SELENA-SLEDAI score at baseline (Spearman's rho -0.233, P = 0.02).
Disease activity and T50 are closely associated. Moreover, T50 levels identify a subgroup of SLE patients with ongoing systemic inflammation as mirrored by increased disease activity. T50 could be a promising biomarker reflecting SLE disease activity and might offer an earlier detection tool for high-risk patients.

Mots-clé
Adult, Calcinosis/blood, Cohort Studies, Female, Humans, Lupus Erythematosus, Systemic/blood, Male, Middle Aged
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/01/2018 11:10
Dernière modification de la notice
20/08/2019 15:48
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