A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.

Détails

ID Serval
serval:BIB_CD155AE5B917
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.
Périodique
Nature Genetics
Auteur(s)
Soranzo N., Spector T.D., Mangino M., Kühnel B., Rendon A., Teumer A., Willenborg C., Wright B., Chen L., Li M., Salo P., Voight B.F., Burns P., Laskowski R.A., Xue Y., Menzel S., Altshuler D., Bradley J.R., Bumpstead S., Burnett M.S., Devaney J., Döring A., Elosua R., Epstein S.E., Erber W., Falchi M., Garner S.F., Ghori M.J., Goodall A.H., Gwilliam R., Hakonarson H.H., Hall A.S., Hammond N., Hengstenberg C., Illig T., König I.R., Knouff C.W., McPherson R., Melander O., Mooser V., Nauck M., Nieminen M.S., O'Donnell C.J., Peltonen L., Potter S.C., Prokisch H., Rader D.J., Rice C.M., Roberts R., Salomaa V., Sambrook J., Schreiber S., Schunkert H., Schwartz S.M., Serbanovic-Canic J., Sinisalo J., Siscovick D.S., Stark K., Surakka I., Stephens J., Thompson J.R., Völker U., Völzke H., Watkins N.A., Wells G.A., Wichmann H.E., Van Heel D.A., Tyler-Smith C., Thein S.L., Kathiresan S., Perola M., Reilly M.P., Stewart A.F., Erdmann J., Samani N.J., Meisinger C., Greinacher A., Deloukas P., Ouwehand W.H., Gieger C.
ISSN
1546-1718 (Electronic)
ISSN-L
1061-4036
Statut éditorial
Publié
Date de publication
2009
Peer-reviewed
Oui
Volume
41
Numéro
11
Pages
1182-1190
Langue
anglais
Notes
Publication types: Journal Article ; Meta-Analysis ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
Résumé
The number and volume of cells in the blood affect a wide range of disorders including cancer and cardiovascular, metabolic, infectious and immune conditions. We consider here the genetic variation in eight clinically relevant hematological parameters, including hemoglobin levels, red and white blood cell counts and platelet counts and volume. We describe common variants within 22 genetic loci reproducibly associated with these hematological parameters in 13,943 samples from six European population-based studies, including 6 associated with red blood cell parameters, 15 associated with platelet parameters and 1 associated with total white blood cell count. We further identified a long-range haplotype at 12q24 associated with coronary artery disease and myocardial infarction in 9,479 cases and 10,527 controls. We show that this haplotype demonstrates extensive disease pleiotropy, as it contains known risk loci for type 1 diabetes, hypertension and celiac disease and has been spread by a selective sweep specific to European and geographically nearby populations.
Mots-clé
Blood Cell Count, Blood Cells/cytology, Chromosomes, Human, Pair 12, Coronary Artery Disease/genetics, Genetic Markers, Genome, Human, Genome-Wide Association Study, Humans, Polymorphism, Single Nucleotide, Selection, Genetic
Pubmed
Web of science
Création de la notice
21/01/2013 11:56
Dernière modification de la notice
20/08/2019 16:47
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