Targeted Immune Interventions for an HIV-1 Cure.

Détails

ID Serval
serval:BIB_CCFE48672672
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Targeted Immune Interventions for an HIV-1 Cure.
Périodique
Trends in molecular medicine
Auteur⸱e⸱s
Perreau M., Banga R., Pantaleo G.
ISSN
1471-499X (Electronic)
ISSN-L
1471-4914
Statut éditorial
Publié
Date de publication
10/2017
Peer-reviewed
Oui
Volume
23
Numéro
10
Pages
945-961
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Combination antiretroviral therapy (cART) induces durable suppression of virus replication but is unable to eradicate HIV. Invariably, virus rebound follows treatment interruption and life-long cART is thus required. Advances have been made in our understanding of HIV latency, identification of HIV cell reservoirs, regulation of HIV-specific immune responses, as well as in the development of broad neutralizing antibodies and putative therapeutic vaccines. These have provided a scientific basis to explore alternative strategies that achieve durable suppression of viremia in the absence of cART, the so-called functional cure. Single intervention strategies have shown promise, albeit with limited efficacy. Consequently, a combination of interventions aiming to stimulate the immune response and prevent new rounds of viral infection and spreading may render the HIV functional cure a feasible goal.

Mots-clé
AIDS Vaccines/therapeutic use, Animals, HIV Antibodies/therapeutic use, HIV Infections/immunology, HIV Infections/therapy, HIV-1/immunology, Humans, Immunotherapy/methods, HIV cure, HIV persistence, HIV reservoir, strategies
Pubmed
Web of science
Création de la notice
25/09/2017 14:19
Dernière modification de la notice
20/08/2019 15:47
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