IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production.

Détails

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Etat: Public
Version: de l'auteur
Licence: CC BY 4.0
ID Serval
serval:BIB_CCD579415CF9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
IL-27-Induced Type 1 Regulatory T-Cells Produce Oxysterols that Constrain IL-10 Production.
Périodique
Frontiers in immunology
Auteur(s)
Vigne S., Chalmin F., Duc D., Clottu A.S., Apetoh L., Lobaccaro J.A., Christen I., Zhang J., Pot C.
ISSN
1664-3224 (Print)
ISSN-L
1664-3224
Statut éditorial
Publié
Date de publication
2017
Peer-reviewed
Oui
Volume
8
Pages
1184
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
The behaviors of lymphocytes, including CD4(+) T helper cells, are controlled on many levels by internal metabolic properties. Lipid metabolites have recently been ascribed a novel function as immune response modulators and perturbation of steroids pathways modulates inflammation and potentially promotes a variety of diseases. However, the impact of lipid metabolism on autoimmune disease development and lymphocyte biology is still largely unraveled. In this line, oxysterols, oxidized forms of cholesterol, have pleiotropic roles on the immune response aside from their involvements in lipid metabolism. The oxysterols 25-hydroxycholesterol (25-OHC) and 7α,25-dihydroxycholesterol (7α,25-OHC) regulate antiviral immunity and immune cell chemotaxis. However, their physiological effects on adaptive immune response in particular on various subset CD4(+) T lymphocytes are largely unknown. Here, we assessed oxysterol levels in subset of CD4(+) T cells and demonstrated that 25-OHC and transcript levels of its synthesizing enzyme, cholesterol 25-hydroxylase, were specifically increased in IL-27-induced type 1 regulatory T (TR1) cells. We further showed that 25-OHC acts as a negative regulator of TR1 cells in particular of IL-10 secretion via liver X receptor signaling. Not only do these findings unravel molecular mechanisms accounting for IL-27 signaling but also they highlight oxysterols as pro-inflammatory mediators that dampens regulatory T cell responses and thus unleash a pro-inflammatory response.
Mots-clé
CD4+ T cells, Epstein–Barr virus-induced G-protein coupled receptor 2 (EBI2), autoimmunity, cholesterol 25-hydroxylase, immunometabolism, nuclear hormone liver X receptor, oxysterols, type 1 regulatory T cells
Pubmed
Web of science
Open Access
Oui
Création de la notice
16/10/2017 17:37
Dernière modification de la notice
30/04/2021 6:37
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