Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.

Détails

ID Serval
serval:BIB_CCCA69D059B0
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Maladaptive exploratory behavior and neuropathology of the PS-1 P117L Alzheimer transgenic mice.
Périodique
Brain Research Bulletin
Auteur(s)
Zufferey V., Vallet P.G., Moeri M., Moulin-Sallanon M., Piotton F., Marin P., Savioz A.
ISSN
1873-2747 (Electronic)
ISSN-L
0361-9230
Statut éditorial
Publié
Date de publication
2013
Volume
94
Pages
17-22
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish. PDF type: Research report
Résumé
Patients with the early-onset Alzheimer's disease P117L mutation in the presenilin-1 gene (PS-1) present pathological hallmarks in the hippocampus, the frontal cortex and the basal ganglia. In the present work we determined by immunohistochemistry which brain regions were injured in the transgenic PS-1 P117L mice, in comparison to their littermates, the B6D2 mice. Furthermore, as these regions are involved in novelty detection, we investigated the behavior of these mice in tests for object and place novelty recognition. Limited numbers of senile plaques and neurofibrillary tangles were detected in aged PS-1 P117L mice in the CA1 only, indicating that the disease is restrained to an initial neuropathological stage. Western blots showed a change in PSD-95 expression (p=0.03), not in NR2A subunit, NR2B subunit and synaptophysin expressions in the frontal cortex, suggesting specific synaptic alterations. The behavioral tests repeatedly revealed, despite a non-significant preference for object or place novelty, maladaptive exploratory behavior of the PS-1 P117L mice in novel environmental conditions, not due to locomotor problems. These mice, unlike the B6D2 mice, were less inhibited to visit the center of the cages (p=0.01) and they continued to move excessively in the presence of a displaced object (p=0.021). Overall, the PS-1 P117L mice appear to be in an initial Alzheimer's disease-like neuropathological stage, and they showed a lack of reaction toward novel environmental conditions.
Pubmed
Web of science
Création de la notice
20/06/2013 17:57
Dernière modification de la notice
20/08/2019 16:47
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