Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study.

Détails

ID Serval
serval:BIB_CC4DDB400285
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Functional connectivity alterations in patients with chronic hepatitis C virus infection: A multimodal MRI study.
Périodique
Journal of viral hepatitis
Auteur(s)
Kharabian Masouleh S., Herzig S., Klose L., Roggenhofer E., Tenckhoff H., Kaiser T., Thöne-Otto A., Wiese M., Berg T., Schroeter M.L., Margulies D.S., Villringer A.
ISSN
1365-2893 (Electronic)
ISSN-L
1352-0504
Statut éditorial
Publié
Date de publication
03/2017
Peer-reviewed
Oui
Volume
24
Numéro
3
Pages
216-225
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Chronic hepatitis C virus (HCV) infection is associated with fatigue and depression. Cognitive impairments are also reported in a smaller number of HCV-positive patients. Recent studies linked HCV to low-grade inflammation in brain. Here, we test the hypothesis that chronic HCV is associated with 3T-neuroimaging-derived grey matter volume (GMV) and functional connectivity alterations in a sample of chronic HCV (1b), without severe liver disease. Regional GMV and resting-state fMRI-derived eigenvector centrality (EC) were compared between 19 HCV-positive patients and 23 healthy controls (all females, 50-69 and 52-64 years, respectively), controlling for white matter hyperintensities and age. Standard tests were used to assess fatigue, depression and cognitive performance. Also, liver fibrosis stage and viral load were quantified among patients. In comparison with controls, HCV-positive patients had higher scores in fatigue and depression, and worse alertness scores. The groups performed similarly in other cognitive domains. We report higher EC in a cluster in the right anterior superior parietal lobule in patients, while no differences are found in GMV. Post hoc functional connectivity analysis showed increased connectivity of this cluster with primary and secondary somatosensory cortex, and temporal and occipital lobes in patients. Higher mean EC in the superior parietal cluster, adjusted for mean framewise displacement, was associated with better memory and attention performance, but not with fatigue, depression, viral load or level of liver fibrosis, among patients. These results suggest a compensatory mechanism in chronic hepatitis C and explain equivocal results in the literature about cognitive deficits in infected persons. Further studies should define the relation of these connectivity changes to the brain's inflammatory activity.

Mots-clé
Aged, Cognition Disorders/epidemiology, Depression/epidemiology, Encephalitis/diagnostic imaging, Encephalitis/epidemiology, Encephalitis/pathology, Fatigue/epidemiology, Female, Gray Matter/diagnostic imaging, Gray Matter/pathology, Hepatitis C, Chronic/complications, Humans, Liver Cirrhosis/pathology, Magnetic Resonance Imaging, Middle Aged, Viral Load, chronic hepatitis-C, cognitive performance, graph centrality, resting state fMRI, voxel-based morphometry
Pubmed
Web of science
Création de la notice
30/11/2016 22:32
Dernière modification de la notice
20/08/2019 16:47
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