Thyrotropin values in patients with micropapillary thyroid cancer versus benign nodular disease.

Détails

ID Serval
serval:BIB_CC355D253BC4
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Thyrotropin values in patients with micropapillary thyroid cancer versus benign nodular disease.
Périodique
Endocrine Practice
Auteur⸱e⸱s
Negro R., Valcavi R., Riganti F., Toulis K.A., Colosimo E., Bongiovanni M., Grassi P., Giovanella L., Gardini G., Piana S.
ISSN
1934-2403 (Electronic)
ISSN-L
1530-891X
Statut éditorial
Publié
Date de publication
2013
Volume
19
Numéro
4
Pages
651-655
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
OBJECTIVE: Studies published in the last few years suggest that increased thyroid-stimulating hormone (TSH) values are associated with increased risk of thyroid cancer and/or a more advanced stage of malignancy. The aim of this study was to explore the hypothesis that TSH may be a risk factor for thyroid cancer initiation, which was tested by comparing TSH concentrations in patients with incidental micro papillary cancer (mPTC) and controls with a negative histologic exam.
METHODS: Patients were retrospectively selected from medical records from 3 district hospitals. Patients with biochemical/histologic evidence of autoimmunity, thyroid function-interfering drugs, and autonomously functioning areas, were excluded. TSH values of 41 patients with an incidental mPTC were then compared with a sex- and age-matched group of patients who had a negative histologic exam at a 4:1 ratio (164 patients).
RESULTS: TSH was not significantly different in the mPTC group compared to the controls (1.1 ± 0.7 vs. 1.3 ± 1.0 mIU/L). After adjustment for age and gender, TSH levels were still not found to be significantly different between groups. In the mPTC group, TSH levels were not found to be a significant predictor of tumor size after adjusting for age and gender (β = 0.035, SE = 0.73, P = .844).
CONCLUSIONS: On the basis of these results, the hypothesis that TSH is involved in de novo oncogenesis of PTC is not supported.
Mots-clé
Adult, Aged, Female, Humans, Male, Middle Aged, Retrospective Studies, Thyroid Gland/pathology, Thyroid Neoplasms/blood, Thyroid Nodule/blood, Thyrotropin/blood
Pubmed
Web of science
Création de la notice
21/01/2015 17:36
Dernière modification de la notice
20/08/2019 16:46
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