Inhibitors of mitogen-activated protein kinases protect axotomized developing neurons.

Détails

ID Serval
serval:BIB_CC05862B502D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Inhibitors of mitogen-activated protein kinases protect axotomized developing neurons.
Périodique
Brain Research
Auteur(s)
Castagné V., Clarke P.G.H.
ISSN
0006-8993[print], 0006-8993[linking]
Statut éditorial
Publié
Date de publication
1999
Volume
842
Numéro
1
Pages
215-219
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Sep 18
Résumé
Axotomy kills developing neurons by mechanisms dependent on protein synthesis and influenced by the redox status. Amongst the redox-regulated transduction systems regulating gene expression are the mitogen-activated protein kinases (MAPKs). In the chick embryo, inhibitors of two different MAPK pathways, including notably the p38 kinase pathway, reduce the number of dying axotomized retinal ganglion cells. The regulation of the genetic events associated to axotomy-induced death thus seems to involve MAPKs.
Mots-clé
Animals, Axotomy, Cell Death/drug effects, Chick Embryo, Dose-Response Relationship, Drug, Enzyme Inhibitors/administration & dosage, Enzyme Inhibitors/pharmacology, Flavonoids/administration & dosage, Flavonoids/pharmacology, Imidazoles/administration & dosage, Imidazoles/pharmacology, Mitogen-Activated Protein Kinase 1/antagonists & inhibitors, Mitogen-Activated Protein Kinase 3, Mitogen-Activated Protein Kinases/antagonists & inhibitors, Neurons/drug effects, Neurons/enzymology, Pyridines/administration & dosage, Pyridines/pharmacology, Retinal Ganglion Cells/drug effects, Superior Colliculi/physiology, p38 Mitogen-Activated Protein Kinases
Pubmed
Web of science
Création de la notice
20/01/2008 18:49
Dernière modification de la notice
20/08/2019 16:46
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