Angiotensin I conversion and vascular reactivity in pathophysiological states in dogs

Détails

ID Serval
serval:BIB_CBF0E31F82C8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Angiotensin I conversion and vascular reactivity in pathophysiological states in dogs
Périodique
Journal of Applied Physiology
Auteur(s)
Leuenberger  P. J., Stalcup  S. A., Greenbaum  L. M., Mellins  R. B., Turino  G. M.
ISSN
0161-7567 (Print)
Statut éditorial
Publié
Date de publication
02/1980
Volume
48
Numéro
2
Pages
308-12
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Feb
Résumé
To determine if angiotension converting enzyme activity is altered by acute pathophysiological insults, we assessed angiotensin I conversion using a blood pressure response technique in anesthetized dogs studied during acute 100% O2 breathing and acute acid-base derangements. Also, we determined systemic vascular reactivity to angiotensin II by measuring the magnitude and duration of the arterial blood pressure response to intra-arterial injections of angiotensin II under these same conditions. Angiotensin I conversion found in normoxia [91 +/- 7 (SD)%] was unchanged by acute acidosis, alkalosis, and hyperoxia. During acute hyperoxia the mean half time of the hypertensive response increased from 68 +/- 25 (SD) s at a PaO2 of 112 +/- 18 (SD) Torr to 100 +/- 34 (SD) s at a PaO2 of 491 +/- 47 (SD) Torr (P less than 0.01). No other pathophysiological condition studied had any effect on reactivity of systemic vasculature to angiotensin II. We conclude that, except during acute hypoxia as previously shown, converting enzyme activity is resistant to other pathophysiological insults and that vascular responsiveness to angiotensin II is enhanced by hyperoxia.
Mots-clé
Acid-Base Imbalance/*metabolism Acidosis/metabolism Acidosis, Respiratory/metabolism Acute Disease Alkalosis/metabolism Alkalosis, Respiratory/metabolism Angiotensin I/*metabolism Angiotensin II/*pharmacology Angiotensins/*metabolism Animals Anoxia/metabolism Dogs Vascular Resistance/drug effects
Pubmed
Web of science
Création de la notice
25/01/2008 10:50
Dernière modification de la notice
20/08/2019 16:46
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