Cognitive improvement in patients with carotid stenosis is independent of treatment type.

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Version: Final published version
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ID Serval
serval:BIB_CBD6FAC9B9CC
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Cognitive improvement in patients with carotid stenosis is independent of treatment type.
Périodique
Swiss Medical Weekly
Auteur(s)
Wapp M., Everts R., Burren Y., Kellner-Weldon F., El-Koussy M., Wiest R., Federspiel A., Michel P., Schroth G.
ISSN
1424-3997 (Electronic)
ISSN-L
0036-7672
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
145
Pages
w14226
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Résumé
Treatment of carotid artery stenosis decreases the long-term risk of stroke and may enhance cerebral blood flow. It is therefore expected to have the potential to prevent cognitive decline or even improve cognition over the long-term. However, intervention itself can cause peri-interventional cerebral infarcts, possibly resulting in a decline of cognitive performance, at least for a short time. We investigated the long-term effects of three treatment methods on cognition and the emotional state one year after intervention. In this prospective observational cohort study, 58 patients with extracranial carotid artery stenosis (≥ 70%) underwent magnetic resonance imaging and assessment of cognition, mood and motor speed before carotid endarterectomy (n = 20), carotid stenting (n = 10) or best medical treatment (n = 28) (i.e., time-point 1 [TP1]), and at one-year follow-up (TP2). Gain scores, reflecting cognitive change after treatment, were built according to performance as (TP2 -TP1)/TP1. Independent of the treatment type, significant improvement in frontal lobe functions, visual memory and motor speed was found. Performance level, motor speed and mood at TP1 were negatively correlated with gain scores, with greater improvement in patients with low performance before treatment. Active therapy, whether conservative or interventional, produces significant improvement of frontal lobe functions and memory in patients with carotid artery disease, independent of treatment type. This effect was particularly pronounced in patients with low cognitive performance prior to treatment.
Mots-clé
Aged, Aged, 80 and over, Carotid Stenosis/psychology, Carotid Stenosis/therapy, Cognition/physiology, Emotions, Endarterectomy, Carotid/adverse effects, Female, Humans, Magnetic Resonance Angiography, Male, Memory, Middle Aged, Neuropsychological Tests, Prospective Studies, Psychiatric Status Rating Scales, Stents/adverse effects, Switzerland, Tomography, X-Ray Computed, Treatment Outcome
Pubmed
Web of science
Open Access
Oui
Création de la notice
21/09/2016 19:29
Dernière modification de la notice
09/12/2020 7:26
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