Plasma apolipoprotein(a) co-deposits with fibrin in inflammatory arthritic joints.

Détails

ID Serval
serval:BIB_CBD161977107
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Plasma apolipoprotein(a) co-deposits with fibrin in inflammatory arthritic joints.
Périodique
American Journal of Pathology
Auteur(s)
Busso N., Dudler J., Salvi R., Péclat V., Lenain V., Marcovina S., Darioli R., Nicod P., So A.K., Mooser V.
ISSN
0002-9440
Statut éditorial
Publié
Date de publication
2001
Peer-reviewed
Oui
Volume
159
Numéro
4
Pages
1445-1453
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Oct
Résumé
Extravascular coagulation and diminished fibrinolysis are processes that contribute to the pathology of both inflammatory arthritis and atherosclerosis. We hypothesized that, given its homology with plasminogen, apolipoprotein (apo) (a), the distinctive glycoprotein of the atherogenic lipoprotein (Lp) (a), may be equally implicated in inflammatory arthritis. We detected the presence of apo(a) as part of Lp(a) in human arthritic synovial fluid. The abundance of apo(a) in synovial fluid rose in proportion to plasma apo(a) levels and was higher in inflammatory arthritides than in osteoarthritis. In addition, apo(a) immunoreactive material, but not apo(a) transcripts, was detected in inflammatory arthritic synovial tissues. These data indicated that synovial fluid apo(a) originates from circulating Lp(a) and that diffusion of Lp(a) through synovial tissue is facilitated in inflammatory types of arthritis. In synovial tissues, apo(a) co-localized with fibrin. These observations could be reproduced in a model of antigen-induced arthritis, using transgenic mice expressing human Lp(a). Although in this mouse model the presence of apo(a) did not change the severity of arthritis, the co-localization of apo(a) with fibrin in synovial tissue suggests that, in humans, apo(a) may modulate locally the fibrinolytic activity and may thus contribute to the persistence of intra-articular fibrin in inflammatory arthritis.
Mots-clé
Animals, Antigens, Apolipoproteins A, Arthritis, Arthritis, Rheumatoid, Fibrin, Humans, Joints, Lipoprotein(a), Mice, Mice, Transgenic, Osteoarthritis, Particle Size, Synovial Fluid, Synovial Membrane
Pubmed
Web of science
Création de la notice
28/01/2008 12:45
Dernière modification de la notice
20/08/2019 16:46
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