A trial with diclofenac HEP plaster as topical treatment in minor sport injuries

Détails

ID Serval
serval:BIB_CBC88418DDE3
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
A trial with diclofenac HEP plaster as topical treatment in minor sport injuries
Périodique
Drugs Under Experimental and Clinical Research
Auteur(s)
Jenoure  P., Segesser  B., Luhti  U., Gremion  G.
ISSN
0378-6501 (Print)
Statut éditorial
Publié
Date de publication
1993
Volume
19
Numéro
3
Pages
125-31
Notes
Clinical Trial
Journal Article
Résumé
Diclofenac HEP plaster was tested in an open study in the treatment of different traumatic sport and overload injuries, to confirm the results of efficacy and tolerability already shown in other clinical studies. A total of 101 patients were assigned to treatment and were eligible for the evaluation of results at the end of a 14-day treatment period. The average score of spontaneous pain, assessed by means of a verbal scale and a visual analogical scale, showed a clear difference in pain rating between the beginning and end of treatment. In general 60% pain reduction was observed. The difference in analgesic activity was already apparent on the 7th day of treatment (-28%). The reduction of pain was confirmed by changes in another subjective sign related to the injury: provoked pain. This symptom decreased in a manner comparable to spontaneous pain: 61% pain reduction after 2 weeks of treatment. Global assessment of efficacy, performed by the investigator at the end of treatment, showed the clear therapeutic activity of local treatment with diclofenac HEP plaster. Satisfactory results were obtained and only 18% of the patients (most of them with chronic and persistent pain) experienced ineffective pain relief at the end of the 2-week treatment. The beneficial effects of diclofenac HEP plaster on pain are confirmed by the patients' assessment, since almost identical scores were obtained. It is striking that the overall tolerance of diclofenac HEP plaster, applied topically twice a day for 2 weeks, was "good" or "excellent" in the 101 patients treated. Any side effect was reported on the patient's card and all the patients completed the study.
Mots-clé
Administration, Cutaneous Adolescent Adult Aged Athletic Injuries/*drug therapy Child Diclofenac/administration & dosage/*analogs & derivatives Female Humans Male Middle Aged Pain Measurement
Pubmed
Web of science
Création de la notice
28/01/2008 13:17
Dernière modification de la notice
20/08/2019 16:46
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