Addressing Evolutionary Questions with Synthetic Biology

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Ressource 1Télécharger: Baier_Schaerli_2021.pdf (601.15 [Ko])
Etat: Public
Version: Author's accepted manuscript
Licence: CC BY 4.0
ID Serval
serval:BIB_CB90D7E34905
Type
Partie de livre
Sous-type
Chapitre: chapitre ou section
Collection
Publications
Institution
Titre
Addressing Evolutionary Questions with Synthetic Biology
Titre du livre
Evolutionary Systems Biology
Auteur⸱e⸱s
Baier Florian, Schaerli Yolanda
Editeur
Springer International Publishing
ISBN
9783030717360
9783030717377
Statut éditorial
Publié
Date de publication
2021
Pages
135-157
Langue
anglais
Résumé
Synthetic biology emerged as an engineering discipline to design and construct artificial biological systems. Synthetic biological designs aim to achieve specific biological behavior, which can be exploited for biotechnological, medical and industrial purposes. In addition, mimicking natural systems using well-characterized biological parts also provides powerful experimental systems to study evolution at the molecular and systems level. A strength of synthetic biology is to go beyond nature’s toolkit, to test alternative versions and to study a particular biological system and its phenotype in isolation and in a quantitative manner. Here, we review recent work that implemented synthetic systems, ranging from simple regulatory circuits, rewired cellular networks to artificial genomes and viruses, to study fundamental evolutionary concepts. In particular, engineering, perturbing or subjecting these synthetic systems to experimental laboratory evolution provides a mechanistic understanding on important evolutionary questions, such as: Why did particular regulatory networks topologies evolve and not others? What happens if we rewire regulatory networks? Could an expanded genetic code provide an evolutionary advantage? How important is the structure of genome and number of chromosomes? Although the field of evolutionary synthetic biology is still in its teens, further advances in synthetic biology provide exciting technologies and novel systems that promise to yield fundamental insights into evolutionary principles in the near future.
Mots-clé
Synthetic biology, Evolutionary Biology, Systems Biology, Evolutionary Systems Biology
Création de la notice
21/01/2022 23:10
Dernière modification de la notice
22/01/2022 8:12
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