Fifty Shades of α-Ketoglutarate on Cellular Programming.

Détails

ID Serval
serval:BIB_CB375784E0F9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fifty Shades of α-Ketoglutarate on Cellular Programming.
Périodique
Molecular cell
Auteur(s)
Di Conza G., Tsai C.H., Ho P.C.
ISSN
1097-4164 (Electronic)
ISSN-L
1097-2765
Statut éditorial
Publié
Date de publication
03/10/2019
Peer-reviewed
Oui
Volume
76
Numéro
1
Pages
1-3
Langue
anglais
Notes
Publication types: Journal Article ; Comment
Publication Status: ppublish
Résumé
High plasticity to utilize different nutrients to adapt metabolic stress is one of the hallmarks for cancer cells. However, the underlying mechanisms by which cancer cells reprogram metabolic machinery in response to metabolic stress remain largely unclear. In this issue of Molecular Cell, Wang et al. (2019) report that glutamate dehydrogenase 1 (GDH1) induces an unconventional regulation of the NF-κB pathway under glucose deprivation, thereby stimulating glycolysis in glioblastomas.
Mots-clé
Brain Neoplasms, Glucose, Glycolysis, Humans, Ketoglutaric Acids, NF-kappa B
Pubmed
Web of science
Création de la notice
08/10/2019 21:05
Dernière modification de la notice
05/09/2020 5:26
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