Primary CNS lymphoma with bilateral symmetric hypothalamic lesions presenting with panhypopituitarism and diabetes insipidus.

Détails

ID Serval
serval:BIB_CB2B295589B9
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Primary CNS lymphoma with bilateral symmetric hypothalamic lesions presenting with panhypopituitarism and diabetes insipidus.
Périodique
Pituitary
Auteur(s)
Layden B.T., Dubner S., Toft D.J., Kopp P., Grimm S., Molitch M.E.
ISSN
1573-7403 (Electronic)
ISSN-L
1386-341X
Statut éditorial
Publié
Date de publication
06/2011
Peer-reviewed
Oui
Volume
14
Numéro
2
Pages
194-197
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article
Publication Status: ppublish
Résumé
We present an unusual case of primary central nervous system (CNS) lymphoma presenting with bilateral symmetric hypothalamic lesions causing diabetes insipidus and hypopituitarism. A 50-year-old male presented initially with mental status changes, polyuria and polydipsia. The patient was determined to have diabetes insipidus (DI) and significant anterior pituitary deficiencies resulting in symptomatic pleural and pericardial effusions. Brain MRI with contrast demonstrated bilateral enhancement of his hypothalamus extending to the optic tract. The extensive diagnostic workup that ensued on his initial presentation was non-diagnostic as he had no obvious site of involvement that was easily accessible to biopsy. With close follow-up, the patient had rapid radiographic progression of his disease to his cerebral hemispheres. He therefore underwent brain biopsy and was diagnosed with primary CNS large B cell lymphoma. Chemotherapy has resulted in disease remission with resolution of MRI findings, but the patient has not had resolution of the hypopituitarism or DI. This case highlights the unique diagnostic challenge of patients with isolated hypothalamic lesions.
Mots-clé
Central Nervous System Neoplasms/complications, Central Nervous System Neoplasms/diagnosis, Central Nervous System Neoplasms/diagnostic imaging, Diabetes Insipidus, Neurogenic/diagnosis, Diabetes Insipidus, Neurogenic/diagnostic imaging, Diabetes Insipidus, Neurogenic/etiology, Diagnosis, Differential, Humans, Hypopituitarism/diagnosis, Hypopituitarism/diagnostic imaging, Hypopituitarism/etiology, Hypothalamic Neoplasms/complications, Hypothalamic Neoplasms/diagnosis, Hypothalamic Neoplasms/diagnostic imaging, Lymphoma/complications, Lymphoma/diagnosis, Lymphoma/diagnostic imaging, Magnetic Resonance Imaging, Male, Middle Aged, Neoplasms, Multiple Primary/complications, Neoplasms, Multiple Primary/diagnosis, Neoplasms, Multiple Primary/diagnostic imaging, Radiography
Pubmed
Web of science
Création de la notice
28/12/2020 15:44
Dernière modification de la notice
29/12/2020 6:26
Données d'usage