Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study.

Détails

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Etat: Public
Version: Final published version
ID Serval
serval:BIB_CB269644304F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Chronic nonbacterial osteomyelitis in children: a retrospective multicenter study.
Périodique
Pediatric Rheumatology Online Journal
Auteur(s)
Kaiser D., Bolt I., Hofer M., Relly C., Berthet G., Bolz D., Saurenmann T.
ISSN
1546-0096 (Electronic)
ISSN-L
1546-0096
Statut éditorial
Publié
Date de publication
2015
Peer-reviewed
Oui
Volume
13
Pages
25
Langue
anglais
Résumé
BACKGROUND: To determine the clinical presentation, current treatment and outcome of children with nonbacterial inflammatory bone disease.
METHODS: Retrospective multicenter study of patients entered into the Swiss Pediatric Rheumatology Working Group registry with a diagnosis of chronic nonbacterial osteomyelitis (CNO) and synovitis acne pustulosis hyperostosis osteitis (SAPHO) syndrome. The charts were reviewed for informations about disease presentation, treatment, course and outcome.
RESULTS: Forty-one children (31 girls and 10 boys) from 6 pediatric hospitals in Switzerland diagnosed between 1995 and 2010 were included in the study. The diagnosis was multifocal CNO (n = 33), unifocal CNO (n = 4) and SAPHO syndrome (n = 4). Mean age at onset of CNO was 9.5 years (range 1.4-15.6) and mean follow-up time was 52 months (range 6-156 months). Most patients (n = 27) had a chronic persistent disease course (>6 months), 8 patients had a course with one or more relapses and 6 patients had only one episode of CNO. Forty nine percent had received at least one course of antibiotics. In 57% treatment with nonsteroidal anti-inflammatory drugs (NSAID) was sufficient to control the disease. Twelve out of 16 children with NSAID failure subsequently received corticosteroids, methotrexate, TNF α inhibitors, bisphosphonates or a combination of these drugs.
CONCLUSIONS: In a multicenter cohort of 41 children 22% started with unifocal lesion with a significant diagnostic delay. A higher proportion presented with chronic persistent disease than with a recurrent form. An osteomyelitis in the pelvic region is significantly associated with other features of juvenile spondylarthritis.
Pubmed
Web of science
Open Access
Oui
Création de la notice
13/07/2015 11:23
Dernière modification de la notice
20/08/2019 15:46
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