Intra-uterine growth restriction induced by maternal low-protein diet causes long-term alterations of thymic structure and function in adult male rat offspring.

Détails

ID Serval
serval:BIB_CAF70B17A491
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Intra-uterine growth restriction induced by maternal low-protein diet causes long-term alterations of thymic structure and function in adult male rat offspring.
Périodique
The British journal of nutrition
Auteur(s)
Armengaud J.B., Dennebouy Z., Labes D., Fumey C., Wilson A., Candotti F., Yzydorczyk C., Simeoni U.
ISSN
1475-2662 (Electronic)
ISSN-L
0007-1145
Statut éditorial
Publié
Date de publication
28/04/2020
Peer-reviewed
Oui
Volume
123
Numéro
8
Pages
892-900
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Early malnutrition, the first environmental cause of intra-uterine growth restriction, impairs development of the thymus. Alterations of the thymic structure and function are reported at young ages in murine and ovine models. However, descriptions of thymic consequences of fetal malnutrition at adulthood are scarce. The present study investigates thymic structure, protein expression and cell selection process observed at postnatal day 180 (PND180) in male offspring of rats exposed to maternal low-protein diet (mLPD) compared with control diet during gestation. The thymic index was lower in adult offspring exposed to mLPD (P < 0·05). The thymic cortico-medullar ratio was lower in adult offspring exposed to mLPD (P < 0·05). At PND180, the protein expression of the lymphotoxin β receptor (P < 0·05), the autoimmune regulator (P < 0·05) and Forkhead Box P3 (FoxP3; P < 0·05) was all significantly lower in the mLPD group. The CD4+:CD8+ single-positive thymocyte subpopulation ratio and CD4+:CD8+ lymphocyte subpopulation ratio were increased in the mLPD group (P < 0·05). Among CD3+ lymphocytes, the proportions of CD4+CD8+ double-positive lymphocytes, CD31+ recent thymic emigrants and CD4+FoxP3+ lymphocytes were not significantly different between mLPD and control groups. These findings suggest mLPD during gestation induced long-lasting alterations in the development of thymic structure and thymic cell maturation and selection process in adult male rat offspring.
Mots-clé
DOHaD, Nutritional immunology, early-life nutrition, intrauterine growth restriction, thymus, Developmental origins of health and disease, Early-life nutrition, Intra-uterine growth restriction, Thymus
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/01/2020 15:26
Dernière modification de la notice
15/07/2020 5:26
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