Reduction of the minimal sequence for initiation of DNA synthesis by qualitative or quantitative changes of an initiator protein.

Détails

ID Serval
serval:BIB_CA9DEEFF2962
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Reduction of the minimal sequence for initiation of DNA synthesis by qualitative or quantitative changes of an initiator protein.
Périodique
Nature
Auteur⸱e⸱s
Dotto G.P., Zinder N.D.
ISSN
0028-0836 (Print)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
1984
Volume
311
Numéro
5983
Pages
279-280
Langue
anglais
Résumé
Initiation of DNA synthesis at an origin of DNA replication involves complex protein-DNA interactions that are still poorly understood. Some of these interactions are highly specific and involve proteins (initiator proteins) thought to be essential for regulation of the initiation process because of their rate-limiting activity. We show here that both qualitative and quantitative changes in one of these proteins have profound effects on protein-DNA interactions at an origin of DNA replication, and are sufficient to reduce to less than one-third the minimal sequence required for initiation. The general implications of these findings are discussed.
Mots-clé
Bacteriophages/genetics, Base Sequence, DNA Replication, DNA-Binding Proteins/physiology, Viral Proteins/metabolism, Virus Replication
Pubmed
Web of science
Création de la notice
24/01/2008 14:58
Dernière modification de la notice
20/08/2019 15:45
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