Sleep Spindles: Mechanisms and Functions.

Détails

ID Serval
serval:BIB_CA719A37E9AB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Sleep Spindles: Mechanisms and Functions.
Périodique
Physiological reviews
Auteur(s)
Fernandez LMJ, Lüthi A.
ISSN
1522-1210 (Electronic)
ISSN-L
0031-9333
Statut éditorial
Publié
Date de publication
01/04/2020
Peer-reviewed
Oui
Volume
100
Numéro
2
Pages
805-868
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Sleep spindles are burstlike signals in the electroencephalogram (EEG) of the sleeping mammalian brain and electrical surface correlates of neuronal oscillations in thalamus. As one of the most inheritable sleep EEG signatures, sleep spindles probably reflect the strength and malleability of thalamocortical circuits that underlie individual cognitive profiles. We review the characteristics, organization, regulation, and origins of sleep spindles and their implication in non-rapid-eye-movement sleep (NREMS) and its functions, focusing on human and rodent. Spatially, sleep spindle-related neuronal activity appears on scales ranging from small thalamic circuits to functional cortical areas, and generates a cortical state favoring intracortical plasticity while limiting cortical output. Temporally, sleep spindles are discrete events, part of a continuous power band, and elements grouped on an infraslow time scale over which NREMS alternates between continuity and fragility. We synthesize diverse and seemingly unlinked functions of sleep spindles for sleep architecture, sensory processing, synaptic plasticity, memory formation, and cognitive abilities into a unifying sleep spindle concept, according to which sleep spindles 1) generate neural conditions of large-scale functional connectivity and plasticity that outlast their appearance as discrete EEG events, 2) appear preferentially in thalamic circuits engaged in learning and attention-based experience during wakefulness, and 3) enable a selective reactivation and routing of wake-instated neuronal traces between brain areas such as hippocampus and cortex. Their fine spatiotemporal organization reflects NREMS as a physiological state coordinated over brain and body and may indicate, if not anticipate and ultimately differentiate, pathologies in sleep and neurodevelopmental, -degenerative, and -psychiatric conditions.
Mots-clé
Animals, Attention, Brain/metabolism, Brain/physiopathology, Brain Waves, Cognition, Humans, Intelligence, Memory, Nervous System Diseases/genetics, Nervous System Diseases/metabolism, Nervous System Diseases/physiopathology, Nervous System Diseases/psychology, Neuronal Plasticity, Periodicity, Sleep Stages, Sleep Wake Disorders/genetics, Sleep Wake Disorders/metabolism, Sleep Wake Disorders/physiopathology, Sleep Wake Disorders/psychology, Time Factors, ion channel, schizophrenia, sleep disorders, sleep regulation, thalamus
Pubmed
Web of science
Création de la notice
15/12/2019 18:45
Dernière modification de la notice
15/07/2020 6:26
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