Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis.

Détails

Ressource 1Télécharger: BIB_CA5C2B672057.P001.pdf (1257.40 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_CA5C2B672057
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Advanced MRI unravels the nature of tissue alterations in early multiple sclerosis.
Périodique
Annals of Clinical and Translational Neurology
Auteur(s)
Bonnier G., Roche A., Romascano D., Simioni S., Meskaldji D., Rotzinger D., Lin Y.C., Menegaz G., Schluep M., Du Pasquier R., Sumpf T.J., Frahm J., Thiran J.P., Krueger G., Granziera C.
ISSN
2328-9503 (Electronic)
ISSN-L
2328-9503
Statut éditorial
Publié
Date de publication
06/2014
Peer-reviewed
Oui
Volume
1
Numéro
6
Pages
423-432
Langue
anglais
Notes
Publication types:
Publication Status: ppublish
Résumé
INTRODUCTION: In patients with multiple sclerosis (MS), conventional magnetic resonance imaging (MRI) provides only limited insights into the nature of brain damage with modest clinic-radiological correlation. In this study, we applied recent advances in MRI techniques to study brain microstructural alterations in early relapsing-remitting MS (RRMS) patients with minor deficits. Further, we investigated the potential use of advanced MRI to predict functional performances in these patients.
METHODS: Brain relaxometry (T1, T2, T2*) and magnetization transfer MRI were performed at 3T in 36 RRMS patients and 18 healthy controls (HC). Multicontrast analysis was used to assess for microstructural alterations in normal-appearing (NA) tissue and lesions. A generalized linear model was computed to predict clinical performance in patients using multicontrast MRI data, conventional MRI measures as well as demographic and behavioral data as covariates.
RESULTS: Quantitative T2 and T2* relaxometry were significantly increased in temporal normal-appearing white matter (NAWM) of patients compared to HC, indicating subtle microedema (P = 0.03 and 0.004). Furthermore, significant T1 and magnetization transfer ratio (MTR) variations in lesions (mean T1 z-score: 4.42 and mean MTR z-score: -4.09) suggested substantial tissue loss. Combinations of multicontrast and conventional MRI data significantly predicted cognitive fatigue (P = 0.01, Adj-R (2) = 0.4), attention (P = 0.0005, Adj-R (2) = 0.6), and disability (P = 0.03, Adj-R (2) = 0.4).
CONCLUSION: Advanced MRI techniques at 3T, unraveled the nature of brain tissue damage in early MS and substantially improved clinical-radiological correlations in patients with minor deficits, as compared to conventional measures of disease.
Pubmed
Open Access
Oui
Création de la notice
15/12/2014 15:04
Dernière modification de la notice
20/08/2019 16:45
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