Impact of strong psychologically stressful events on the development of Alzheimer disease: a possible role of epigenetic?

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Ressource 1Télécharger: BIB_CA5BC8351630.P001.pdf (349.63 [Ko])
Etat: Public
Version: Après imprimatur
ID Serval
serval:BIB_CA5BC8351630
Type
Mémoire
Sous-type
(Mémoire de) maîtrise (master)
Collection
Publications
Institution
Titre
Impact of strong psychologically stressful events on the development of Alzheimer disease: a possible role of epigenetic?
Auteur⸱e⸱s
SCHIPANI F.
Directeur⸱rice⸱s
GHIKA J.
Codirecteur⸱rice⸱s
DEMONET J.-F.
Détails de l'institution
Université de Lausanne, Faculté de biologie et médecine
Statut éditorial
Acceptée
Date de publication
2014
Langue
anglais
Nombre de pages
21
Résumé
Alzheimer disease (AD) is the most common neurodegenerative dementia. It leads to a progressive loss of cognitive functions, especially memory. Most of AD cases are sporadic, resulting from the interplay of genetic and environmental factors which get involved in the regulation of the expression of thousands of genes, a mechanism called epigenetic[1]. Epigenetic modifications, by modifying genes transcription, help to orchestrate the phenotypical changes linked to development, aging or even diseases and cancer[2]. In AD, recent studies showed rapid, dynamic and persistent epigenetic mutations that are believed to have consequences on brain functions. One of the earliest biomarker of AD is amyloïd-beta deposition in the brain. According to current studies, deposition of amyloïd-beta begins approximately 20 years before the first symptoms linked to the disease, which questions us about what could have happened around or before that time. During this study, we tried to identify a possible correlation between the experiencing of a strong psychologically stressful life event, which could have lead to several epigenetic changes, and the occurrence of Mild Cognitive Impairment (MCI) or AD dozens of years later. We also tried to highlight a possible difference in the delay between MCI and AD patients.
Mots-clé
Alzheimer's disease, epigenetic, stressful events, trauma, latency
Création de la notice
03/09/2015 11:42
Dernière modification de la notice
20/08/2019 16:45
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