Advances in the understanding and management of angioimmunoblastic T-cell lymphoma.

Détails

ID Serval
serval:BIB_C9590EBDAC8B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Advances in the understanding and management of angioimmunoblastic T-cell lymphoma.
Périodique
British Journal of Haematology
Auteur(s)
de Leval L., Gisselbrecht C., Gaulard P.
ISSN
1365-2141 (Electronic)
ISSN-L
0007-1048
Statut éditorial
Publié
Date de publication
2010
Volume
148
Numéro
5
Pages
673-689
Langue
anglais
Notes
Publication types: Journal Article ; Review
Résumé
Angioimmunoblastic T-cell lymphoma (AITL) is a distinct peripheral T-cell lymphoma (PTCL) entity with peculiar clinical and pathological features. The recent identification of follicular helper T (T(FH)) cell as the cell of origin of this neoplasm represents a major step in our understanding of the pathobiological characteristics of the disease and should, in the future, clarify the diagnostic criteria for AITL and help to delineate its spectrum, especially from PTCL, not otherwise specified (PTCL, NOS). Deciphering the pathogenesis of the disease is needed to identify targets for new therapies that are expected to improve the poor outcome of AITL patients, when treated with conventional chemotherapy regimens. In this respect, efforts will be needed to evaluate promising innovative therapies in prospective clinical trials.
Mots-clé
Antineoplastic Agents/administration & dosage, Cytogenetics, Diagnosis, Differential, Humans, Immunophenotyping, Lymphoma, T-Cell, Peripheral/diagnosis, Lymphoma, T-Cell, Peripheral/genetics, Lymphoma, T-Cell, Peripheral/</QualifierName> <QualifierName MajorTopicYN="N">, Prognosis, T-Lymphocytes, Helper-Inducer/metabolism
Pubmed
Open Access
Oui
Création de la notice
22/10/2010 9:52
Dernière modification de la notice
20/08/2019 15:44
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