Histopathologic Validation of the Sentinel Node Technique for Early-Stage Cervical Cancer Patients.

Détails

ID Serval
serval:BIB_C9015444AC36
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Histopathologic Validation of the Sentinel Node Technique for Early-Stage Cervical Cancer Patients.
Périodique
Annals of surgical oncology
Auteur(s)
Mathevet P., Guani B., Ciobanu A., Lamarche E.M., Boutitie F., Balaya V., Lecuru F.
ISSN
1534-4681 (Electronic)
ISSN-L
1068-9265
Statut éditorial
Publié
Date de publication
07/2021
Peer-reviewed
Oui
Volume
28
Numéro
7
Pages
3629-3635
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The sentinel lymph node (SLN) biopsy may be an alternative to systematic lymphadenectomy in early cervical cancer. The SLN biopsy is less morbid and has been shown to have high sensitivity for metastasis detection. However, the sensitivity of the SLN technique might be overevaluated because SLNs are examined with ultra-staging, and non-sentinel nodes usually are examined only with routine techniques. This study aimed to validate the negative predictive value (NPV) of the SLN technique by the ultra-staging of SLNs and non-sentinel nodes (NSLNs).
The SENTICOL 1 study data published in 2011 were used. All nodes (i.e., SLNs and NSLNs) were secondarily subjected to ultra-staging. The ultra-staging consisted of sectioning every 200 µm, in addition to immunohistochemistry. Moreover, the positive slides and 10% of the negative slides were reviewed.
The study enrolled 139 patients, and SLNs were detected in 136 (97.8%) of these patiets. Bilateral SLNs were detected in 104 (76.5%) of the 136 patients. A total of 2056 NSLNs were identified (median, 13 NSLNs per patient; range 1-54). Of the 136 patients with SLNs, 23 were shown to have positive SLNs after serial sectioning and immunohistochemical staining. The NSLNs were metastatic in six patients. In the case of bilateral SLN detection, the NPV was 100%, with no false-negatives (FNs).
The pelvic SLN technique is safe and trustworthy for determining the nodal status of patients with early-stage cervical cancer. In the case of optimal mapping with bilateral detection, the NPV was found to be 100%.
Mots-clé
Female, Humans, Lymph Node Excision, Lymph Nodes/pathology, Lymph Nodes/surgery, Lymphatic Metastasis, Neoplasm Staging, Sentinel Lymph Node/pathology, Sentinel Lymph Node/surgery, Sentinel Lymph Node Biopsy, Uterine Cervical Neoplasms/pathology, Uterine Cervical Neoplasms/surgery
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/11/2020 16:05
Dernière modification de la notice
17/06/2021 6:35
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