Trends and prediction of antimicrobial susceptibility in urinary bacteria isolated in European emergency departments: the EuroUTI 2010-2016 Study.
Détails
ID Serval
serval:BIB_C895B3E29737
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Trends and prediction of antimicrobial susceptibility in urinary bacteria isolated in European emergency departments: the EuroUTI 2010-2016 Study.
Périodique
The Journal of antimicrobial chemotherapy
Collaborateur⸱rice⸱s
EuroUTI 2010-2016 tudy Group
Contributeur⸱rice⸱s
Roman F., Llorens P., Salvi F., Galeazzi R., Ortega M., Marco F., Martinez Ortiz de Zarate M., Figueroa Ceron R., Trovato F.M., Carpinteri G., Moustafa F., Romaszko J.P., Pedersen M., Westh H., Dejaune P., Fihman V., Joost I., Blumel B., Parrilla Ruiz F.M., Alvarez Corral G., Bieler D., Bergmann H., Granzer H., Carron P.N., Prod'hom G., Greub G., Gonzalez Del Castillo J.M., Candel Gonzalez F.J., Juvin M.E., Occelli C., Ruimy R., Claret P.G., Lavigne J.P., Hausfater P., Robert J., Ramacciati N., Mencacci A., Tartaglia D., Rossi L., Ojetti V., Petruzziello C., Fiori B., Bonenfant J., Piau-Couape C., Dejoies L., Garcia-Garcia Á., Cores-Calvo O., Van Den Brand C.L., van Veen S.Q., Laribi S., Lartigue M.F.
ISSN
1460-2091 (Electronic)
ISSN-L
0305-7453
Statut éditorial
Publié
Date de publication
01/10/2019
Peer-reviewed
Oui
Volume
74
Numéro
10
Pages
3069-3076
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
To assess recent trends in susceptibility to antibiotics among urinary isolates isolated in European emergency departments (EDs) and to identify isolates with a high (90% or more) predicted probability of susceptibility to fluoroquinolones or third-generation cephalosporins (3GCs).
In this cross-sectional study, we included urine cultures obtained from adult patients between 2010 and 2016 in 24 European EDs. Temporal trends were assessed using time-series analysis and multivariate logistic models. Multivariate logistic models were also used to predict susceptibility to fluoroquinolones or 3GCs from patient age and sex, year, month and ED.
We included 88242 isolates. Time-series analysis found a significant increase in susceptibility to fluoroquinolones and no significant trend for susceptibility to 3GCs. Adjusting for patient age and sex, ED and organism, multivariate models showed that susceptibility to 3GCs decreased from 2014 to 2016, while susceptibility to fluoroquinolones increased in 2015 and 2016. Among isolates from 2016, multivariate models predicted high probability of susceptibility to fluoroquinolones in 11% of isolates (positive predictive value 91%) and a high probability of susceptibility to 3GCs in 35% of isolates (positive predictive value 94%).
Susceptibility of ED urinary isolates to fluoroquinolones increased from 2014, while susceptibility to 3GCs decreased from 2015. Predictive models identified isolates with a high probability of susceptibility to fluoroquinolones or 3GCs. The ability of such models to guide the empirical treatment of pyelonephritis in the ED remains to be determined.
In this cross-sectional study, we included urine cultures obtained from adult patients between 2010 and 2016 in 24 European EDs. Temporal trends were assessed using time-series analysis and multivariate logistic models. Multivariate logistic models were also used to predict susceptibility to fluoroquinolones or 3GCs from patient age and sex, year, month and ED.
We included 88242 isolates. Time-series analysis found a significant increase in susceptibility to fluoroquinolones and no significant trend for susceptibility to 3GCs. Adjusting for patient age and sex, ED and organism, multivariate models showed that susceptibility to 3GCs decreased from 2014 to 2016, while susceptibility to fluoroquinolones increased in 2015 and 2016. Among isolates from 2016, multivariate models predicted high probability of susceptibility to fluoroquinolones in 11% of isolates (positive predictive value 91%) and a high probability of susceptibility to 3GCs in 35% of isolates (positive predictive value 94%).
Susceptibility of ED urinary isolates to fluoroquinolones increased from 2014, while susceptibility to 3GCs decreased from 2015. Predictive models identified isolates with a high probability of susceptibility to fluoroquinolones or 3GCs. The ability of such models to guide the empirical treatment of pyelonephritis in the ED remains to be determined.
Pubmed
Création de la notice
18/07/2019 17:36
Dernière modification de la notice
08/09/2020 6:23
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