Functional, biological, and radiological evaluation of the pancreaticojejunal anastomosis 1 year after pancreatoduodenectomy: a prospective study.

Détails

Ressource 1Télécharger: Published MRI article-Langenbecks.pdf (600.47 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_C879F27CE20A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Functional, biological, and radiological evaluation of the pancreaticojejunal anastomosis 1 year after pancreatoduodenectomy: a prospective study.
Périodique
Langenbeck's archives of surgery
Auteur⸱e⸱s
Joliat G.R., Allemann P., Labgaa I., Demartines N., Vietti Violi N., Schmidt S., Schäfer M.
ISSN
1435-2451 (Electronic)
ISSN-L
1435-2443
Statut éditorial
Publié
Date de publication
22/08/2023
Peer-reviewed
Oui
Volume
408
Numéro
1
Pages
326
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
This prospective study aimed to analyze the functional, biological, and radiological aspects of the pancreatic anastomosis 1 year after pancreatoduodenectomy (PD).
From 2016 to 2019, patients with PD indication were screened. Questionnaires about pancreas insufficiency, fecal elastase tests, and magnetic resonance imaging (MRI) were performed before and 1 year after PD.
Twenty patients were prospectively included. The only difference between pre- and postoperative questionnaires was constipation (less frequent 1 year after PD). Median pre- and postoperative fecal elastase levels were 96 μg/g (IQR 15-196, normal value > 200) and 15 μg/g (IQR 15-26, p = 0.042). There were no significant differences in terms of main pancreatic duct (MPD) size (4, IQR 3-5 vs. 4 mm, IQR 3-5, p = 0.892), border regularity, stenosis, visibility, image improvement, and secondary pancreatic duct dilation before and after secretin injection. All patients but one (2 refused and 2 were lost to follow-up, 15/16, 94%) had a patent pancreaticojejunal anastomosis on 1-year MRI.
Although median 1-year fecal elastase was significantly lower than preoperatively, suggesting that exocrine secretion was altered, the anatomical outcome as assessed by MRI was excellent showing high patency rate (15/16, 94%) at 1 year. This emphasizes the difference between anatomy and function.
Mots-clé
Humans, Prospective Studies, Pancreaticoduodenectomy, Radiography, Pancreaticojejunostomy, Constriction, Pathologic, Cancer, Complication, Pancreatectomy, Permeability
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/09/2023 11:29
Dernière modification de la notice
29/02/2024 16:56
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