Structure, sequence and polymorphism in the HLA-D region

Détails

ID Serval
serval:BIB_C8368415765C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Structure, sequence and polymorphism in the HLA-D region
Périodique
Immunological Reviews
Auteur(s)
Trowsdale  J., Young  J. A., Kelly  A. P., Austin  P. J., Carson  S., Meunier  H., So  A., Erlich  H. A., Spielman  R. S., Bodmer  J., et al.
ISSN
0105-2896 (Print)
Statut éditorial
Publié
Date de publication
07/1985
Volume
85
Pages
5-43
Notes
Comparative Study
Journal Article
Review --- Old month value: Jul
Résumé
Molecular analysis of the HLA-D region has uncovered a complex array of related genes encompassing a minimum of 6 alpha and 7 beta chain sequences. A high level of polymorphism is characteristic of the DQ alpha and beta genes, as well as DR beta. The DP genes, both alpha and beta, are also polymorphic, though to a lesser extent. The genes fit into the previously established loci: DP, DQ and DR, except for a newly-discovered sequence, DZ alpha, which is approximately equally related to all of the other alpha chain genes. Analysis of the polymorphism and evolution of the HLA-D region, by examination of the sequences, calls for several independent duplication events in the generation of this family of genes.
Mots-clé
Base Sequence Chromosome Mapping Cloning, Molecular Cosmids DNA/genetics DNA Restriction Enzymes Evolution HLA-DP Antigens HLA-DQ Antigens HLA-DR Antigens Histocompatibility Antigens Class II/*genetics Humans Molecular Conformation *Polymorphism, Genetic Transfection
Pubmed
Web of science
Création de la notice
25/01/2008 9:39
Dernière modification de la notice
20/08/2019 16:43
Données d'usage