The parallel lives of angiogenesis and immunosuppression: cancer and other tales.

Détails

ID Serval
serval:BIB_C82F5E3CB774
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
The parallel lives of angiogenesis and immunosuppression: cancer and other tales.
Périodique
Nature Reviews. Immunology
Auteur(s)
Motz G.T., Coukos G.
ISSN
1474-1741 (Electronic)
ISSN-L
1474-1733
Statut éditorial
Publié
Date de publication
2011
Volume
11
Numéro
10
Pages
702-711
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: epublish. pdf type: Perspectives
Résumé
Emerging evidence indicates that angiogenesis and immunosuppression frequently occur simultaneously in response to diverse stimuli. Here, we describe a fundamental biological programme that involves the activation of both angiogenesis and immunosuppressive responses, often through the same cell types or soluble factors. We suggest that the initiation of these responses is part of a physiological and homeostatic tissue repair programme, which can be co-opted in pathological states, notably by tumours. This view can help to devise new cancer therapies and may have implications for aseptic tissue injury, pathogen-mediated tissue destruction, chronic inflammation and even reproduction.
Mots-clé
Animals, Cell Communication/immunology, Cytokines/immunology, Cytokines/metabolism, Homeostasis/immunology, Humans, Immune Tolerance, Immunosuppression, Immunosuppressive Agents/immunology, Immunosuppressive Agents/metabolism, Intercellular Signaling Peptides and Proteins/immunology, Intercellular Signaling Peptides and Proteins/metabolism, Mice, Myeloid Cells/cytology, Myeloid Cells/immunology, Neoplasm Proteins/immunology, Neoplasm Proteins/metabolism, Neoplasms/immunology, Neoplasms/metabolism, Neovascularization, Pathologic/immunology, Neovascularization, Pathologic/metabolism, Stromal Cells/cytology, Stromal Cells/immunology, T-Lymphocyte Subsets/cytology, T-Lymphocyte Subsets/immunology, Tumor Microenvironment/immunology
Pubmed
Web of science
Création de la notice
14/10/2014 12:43
Dernière modification de la notice
20/08/2019 16:43
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