SYNDROC: microcomputer based differential diagnosis of malformation patterns

Détails

ID Serval
serval:BIB_C7FCDB5C1528
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
SYNDROC: microcomputer based differential diagnosis of malformation patterns
Périodique
Archives of Disease in Childhood
Auteur(s)
Schorderet  D., Aebischer  P.
ISSN
1468-2044 (Electronic)
Statut éditorial
Publié
Date de publication
03/1985
Volume
60
Numéro
3
Pages
248-51
Notes
Journal Article --- Old month value: Mar
Résumé
The differential diagnosis of human malformation patterns is difficult because of their great number and low occurrence. To compensate for deficiencies in experience, the authors have developed a microcomputer based differential diagnosis for dysmorphic syndromes. Written in PL/I-80 and using a MDBS III data base containing more than 700 signs and 300 syndromes, the algorithm of SYNDROC, the program's name, is built on three different approaches. An initial differential diagnosis is given by a pseudo-Bayesian method. Its refinement is possible through an heuristic approach, and undiagnosed cases are stored for subsequent Boolean retrieval, thus permitting the recognition of new dysmorphic disorders. The reliability of the program was tested in a retrospective study based on 100 dysmorphic cases. The results showed a 95% agreement between the first two diagnoses suggested by SYNDROC and the diagnosis made by experienced geneticists.
Mots-clé
Abnormalities, Multiple/*diagnosis Child *Computers Diagnosis, Computer-Assisted/*methods Diagnosis, Differential Humans *Microcomputers Retrospective Studies Software
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2008 13:58
Dernière modification de la notice
20/08/2019 16:43
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