Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse.

Détails

ID Serval
serval:BIB_C7B01273E737
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Presence of Leishmania RNA Virus 1 in Leishmania guyanensis Increases the Risk of First-Line Treatment Failure and Symptomatic Relapse.
Périodique
Journal of Infectious Diseases
Auteur⸱e⸱s
Bourreau E., Ginouves M., Prévot G., Hartley M.A., Gangneux J.P., Robert-Gangneux F., Dufour J., Sainte-Marie D., Bertolotti A., Pratlong F., Martin R., Schütz F., Couppié P., Fasel N., Ronet C.
ISSN
1537-6613 (Electronic)
ISSN-L
0022-1899
Statut éditorial
Publié
Date de publication
2016
Peer-reviewed
Oui
Volume
213
Numéro
1
Pages
105-111
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Treatment failure and symptomatic relapse are major concerns in American tegumentary leishmaniasis (TL). Such complications are seen frequently in Leishmania guyanensis infections, in which patients respond variously to first-line antileishmanials and are more prone to develop chronic cutaneous leishmaniasis. The factors underlying this pathology, however, are unknown. Recently, we reported that a double-stranded RNA virus, Leishmania RNA virus 1 (LRV1), nested within L. guyanensis parasites is able to exacerbate experimental murine leishmaniasis by inducing a hyperinflammatory response. This report investigates the prevalence of LRV1 in human L. guyanensis infection and its effect on treatment efficacy, as well as its correlation to symptomatic relapses after the completion of first-line treatment. In our cohort of 75 patients with a diagnosis of primary localized American TL, the prevalence of LRV1-positive L. guyanensis infection was elevated to 58%. All patients infected with LRV1-negative L. guyanensis were cured after 1 dose (22 of 31 [71%]) or 2 doses (31 of 31 [100%]) of pentamidine. In contrast, 12 of 44 LRV1-positive patients (27%) presented with persistent infection and symptomatic relapse that required extended therapy and the use of second-line drugs. Finally, LRV1 presence was associated with a significant increase in levels of intra-lesional inflammatory markers. In conclusion, LRV1 status in L. guyanensis infection is significantly predictive (P = .0009) of first-line treatment failure and symptomatic relapse and has the potential to guide therapeutic choices in American TL.
Mots-clé
Adult, Antiprotozoal Agents/pharmacology, Antiprotozoal Agents/therapeutic use, Cohort Studies, Female, Humans, Leishmania guyanensis/drug effects, Leishmania guyanensis/virology, Leishmaniasis, Mucocutaneous/drug therapy, Leishmaniasis, Mucocutaneous/epidemiology, Leishmaniavirus, Male, Pentamidine/pharmacology, Pentamidine/therapeutic use, Recurrence, Treatment Failure
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/01/2016 8:22
Dernière modification de la notice
20/08/2019 15:43
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