CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.
Détails
ID Serval
serval:BIB_C792858A09ED
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
CD19, the earliest differentiation antigen of the B cell lineage, bears three extracellular immunoglobulin-like domains and an Epstein-Barr virus-related cytoplasmic tail.
Périodique
Journal of Experimental Medicine
ISSN
0022-1007[print], 0022-1007[linking]
Statut éditorial
Publié
Date de publication
1988
Volume
168
Numéro
3
Pages
1205-1210
Langue
anglais
Notes
Publication types: Comparative Study ; Journal Article
Résumé
The isolation and expression of a full-length cDNA clone encoding the B cell-specific glycoprotein CD19 is reported. The sequence of the cDNA predicts a glycosylated integral membrane protein with a precursor molecular weight of 51.8 x 10(3) and an extracellular domain organized into three contiguous Ig-like sub-domains. The cytoplasmic domain bears significant relatedness to two proteins encoded by the Epstein-Barr virus and the int-1 oncogene. CD19 transcripts are restricted to members of the B cell lineage, being most abundant in pre-B cell lines and least abundant in plasmacytomas.
Mots-clé
Amino Acid Sequence, Antigens, CD19, Antigens, Differentiation, B-Lymphocyte/genetics, Base Sequence, Blotting, Northern, Cloning, Molecular, DNA/genetics, Humans, Membrane Glycoproteins/genetics, Molecular Sequence Data, Molecular Structure
Pubmed
Création de la notice
25/08/2010 15:57
Dernière modification de la notice
20/08/2019 16:42
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