Development of a pediatric eosinophilic esophagitis activity index (ped-EEsAI): International experts propose dysphagia, whitish exudates on endoscopy , and intraepithelial eosinophili count as major items related to EoE activity
Détails
ID Serval
serval:BIB_C77F2172836F
Type
Actes de conférence (partie): contribution originale à la littérature scientifique, publiée à l'occasion de conférences scientifiques, dans un ouvrage de compte-rendu (proceedings), ou dans l'édition spéciale d'un journal reconnu (conference proceedings).
Sous-type
Abstract (résumé de présentation): article court qui reprend les éléments essentiels présentés à l'occasion d'une conférence scientifique dans un poster ou lors d'une intervention orale.
Collection
Publications
Institution
Titre
Development of a pediatric eosinophilic esophagitis activity index (ped-EEsAI): International experts propose dysphagia, whitish exudates on endoscopy , and intraepithelial eosinophili count as major items related to EoE activity
Titre de la conférence
Annual Meeting of the Swiss Society of Gastroenterology, Swiss Society for Visceral Surgery, Swiss Association for the Study of the Liver, Swiss Association of Clinical Nutrition
Adresse
Interlaken, Switzerland, September 23-24, 2010
ISBN
1424-3997
Statut éditorial
Publié
Date de publication
2010
Volume
140
Série
Swiss Medical Weekly
Pages
26S
Langue
anglais
Résumé
Background and Aims: The international EEsAI study group
aims to develop, validate and evaluate the first pediatric EoE
activity index (ped-EEsAI). We report on results of phase 1,
which aims to generate candidate items.
Methods: This study involves 3 phases: (1) item generation, (2) index derivation and
testing on a first patient cohort, and (3) validation in a second
cohort. In phase 1, item generation, weighting and reduction are
achieved through a Delphi process with an international EoE
expert group. The experts proposed and ranked candidate
items on a 7-point Likert scale (0 = no, 6 = perfect relationship
with EoE activity).
Results: 23 international EoE experts proposed and ranked 39 items (20 clinical, 6 endoscopic, 8
histologic, 5 laboratory items). Rank order for clinical items:
dysphagia related to food consistencies (median 5, range 2-6),
severity of dysphagia (5, 3-6), frequency of dysphagia episodes
(5, 3-6), regurgitation and vomiting (4, 2-5), response to dietary
restrictions (4, 1-6); endoscopic items: whitish exudates (5, 3-6),
furrowing (4, 3-6), corrugated rings (4, 2-6), linear shearing (4,
2-6), strictures (3, 2-6); histologic items: intraepithelial
eosinophil count (5, 4-6), lamina propria fibrosis (3, 2-6), basal
layer enlargement (3, 1-5); laboratory items: % blood
eosinophils (3, 0-5).
Conclusions: These items will now be
reduced in further Delphi rounds, tested on a cohort of 100
pediatric EoE patients and validated in a second independent
cohort, resulting in a robust, broadly accepted disease activity
index for use in clinical trials and daily care.
aims to develop, validate and evaluate the first pediatric EoE
activity index (ped-EEsAI). We report on results of phase 1,
which aims to generate candidate items.
Methods: This study involves 3 phases: (1) item generation, (2) index derivation and
testing on a first patient cohort, and (3) validation in a second
cohort. In phase 1, item generation, weighting and reduction are
achieved through a Delphi process with an international EoE
expert group. The experts proposed and ranked candidate
items on a 7-point Likert scale (0 = no, 6 = perfect relationship
with EoE activity).
Results: 23 international EoE experts proposed and ranked 39 items (20 clinical, 6 endoscopic, 8
histologic, 5 laboratory items). Rank order for clinical items:
dysphagia related to food consistencies (median 5, range 2-6),
severity of dysphagia (5, 3-6), frequency of dysphagia episodes
(5, 3-6), regurgitation and vomiting (4, 2-5), response to dietary
restrictions (4, 1-6); endoscopic items: whitish exudates (5, 3-6),
furrowing (4, 3-6), corrugated rings (4, 2-6), linear shearing (4,
2-6), strictures (3, 2-6); histologic items: intraepithelial
eosinophil count (5, 4-6), lamina propria fibrosis (3, 2-6), basal
layer enlargement (3, 1-5); laboratory items: % blood
eosinophils (3, 0-5).
Conclusions: These items will now be
reduced in further Delphi rounds, tested on a cohort of 100
pediatric EoE patients and validated in a second independent
cohort, resulting in a robust, broadly accepted disease activity
index for use in clinical trials and daily care.
Web of science
Création de la notice
02/02/2011 9:39
Dernière modification de la notice
20/08/2019 16:42
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