Microalbuminuria and hyperfiltration in subjects with nephro-urological disorders.

Détails

Ressource 1Télécharger: serval:BIB_C769A79D99AF.P001 (142.93 [Ko])
Etat: Public
Version: de l'auteur
Licence: Non spécifiée
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ID Serval
serval:BIB_C769A79D99AF
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Microalbuminuria and hyperfiltration in subjects with nephro-urological disorders.
Périodique
Nephrology, Dialysis, Transplantation
Auteur(s)
Cachat F., Combescure C., Chehade H., Zeier G., Mosig D., Meyrat B., Frey P., Girardin E.
ISSN
1460-2385 (Electronic)
ISSN-L
0931-0509
Statut éditorial
Publié
Date de publication
2013
Volume
28
Numéro
2
Pages
386-391
Langue
anglais
Notes
Publication types: Journal ArticlePublication Status: ppublish
Résumé
BACKGROUND: Microalbuminuria (MA) has been shown to be an early biomarker of renal damage. It is postulated that MA is the early result of hyperfiltration, which could evolve into glomerular sclerosis and renal failure if hyperfiltration is left untreated. We hypothesized that MA is a good indicator of hyperfiltration in children with kidney disorders, obviating the need to calculate the filtration fraction (FF).
METHODS: A total of 155 children or young adults were prospectively included [42 single kidney (SK), 61 vesico-ureteral reflux, 23 obstructive uropathies, 29 other kidney diseases]. We measured inulin, para-aminohippuric acid clearances, FF and MA. Prediction of hyperfiltration was explored by studying the association between the FF and other variables such as urinary albumin (Alb), urinary albumin-creatinine ratio (ACR) and creatinine clearance.
RESULTS: A significant but weak association between urinary Alb or ACR and FF was found in subjects with an SK (Spearman correlation coefficients 0.32 and 0.19, respectively). Multivariate analysis also showed that urinary Alb and ACR significantly predict FF only in subjects with an SK (r(2) = 0.17, P = 0.01 and r(2) = 0.13, P = 0.02, respectively). This holds true only in subjects with an SK and inulin clearance >90 mL/min/1.73 m(2) (r(2) = 0.41, P < 0.001). There was no association between creatinine clearance and FF.
CONCLUSIONS: MA is not associated with FF in our subjects with nephro-urological disorders, except in those with an SK, where the association is weak, indicating that MA is due to other mechanisms than high FF and cannot predict hyperfiltration in such groups.
Pubmed
Web of science
Open Access
Oui
Création de la notice
12/04/2013 18:56
Dernière modification de la notice
25/09/2019 7:10
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