Antigenic analysis of the repeat domain of the circumsporozoite protein of Plasmodium vivax

Détails

ID Serval
serval:BIB_C7581B5DE6CE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Antigenic analysis of the repeat domain of the circumsporozoite protein of Plasmodium vivax
Périodique
Journal of Immunology
Auteur⸱e⸱s
Romero  P., Heimer  E. P., Herrera  S., Felix  A. M., Nussenzweig  R. S., Zavala  F.
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
09/1987
Volume
139
Numéro
5
Pages
1679-82
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S. --- Old month value: Sep 1
Résumé
In the present study we analyzed the fine specificity of mouse monoclonal and human polyclonal antibodies directed against the repeat domain of the circumsporozoite (CS) protein of the human malaria parasite, Plasmodium vivax. Five synthetic peptides, representing monomeric and dimeric repeats of this malarial antigen, were assayed for their capacity to inhibit the binding of these antibodies to a yeast-derived recombinant CS protein. The results revealed the existence of at least two distinct repeated overlapping epitopes in the CS protein of P. vivax. Furthermore, polyclonal sera contain antibodies which recognize additional determinants not represented by the synthetic repeat peptides. Some of these sera contain antibodies recognizing a region flanking the repeat domain (region I). The present findings are in contrast with the antibody response in rodents and humans to the Plasmodium falciparum CS protein, which is directed against a single repeated immunodominant epitope.
Mots-clé
Animals Antibodies, Monoclonal/immunology Antibody Specificity Antigens, Protozoan/*immunology Antigens, Surface/*immunology Epitopes/immunology Humans Mice Plasmodium vivax/*immunology *Protozoan Proteins
Pubmed
Web of science
Création de la notice
28/01/2008 11:27
Dernière modification de la notice
20/08/2019 15:42
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