Prognostic factors in advanced cancer patients: evidence-based clinical recommendations--a study by the Steering Committee of the European Association for Palliative Care.

Détails

ID Serval
serval:BIB_C70B4FBA27DE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Prognostic factors in advanced cancer patients: evidence-based clinical recommendations--a study by the Steering Committee of the European Association for Palliative Care.
Périodique
Journal of clinical oncology
Auteur(s)
Maltoni M., Caraceni A., Brunelli C., Broeckaert B., Christakis N., Eychmueller S., Glare P., Nabal M., Viganò A., Larkin P., De Conno F., Hanks G., Kaasa S.
Collaborateur(s)
Steering Committee of the European Association for Palliative Care
ISSN
0732-183X (Print)
ISSN-L
0732-183X
Statut éditorial
Publié
Date de publication
01/09/2005
Peer-reviewed
Oui
Volume
23
Numéro
25
Pages
6240-6248
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
To offer evidence-based clinical recommendations concerning prognosis in advanced cancer patients.
A Working Group of the Research Network of the European Association for Palliative Care identified clinically significant topics, reviewed the studies, and assigned the level of evidence. A formal meta-analysis was not feasible because of the heterogeneity of published studies and the lack of minimal standards in reporting results. A systematic electronic literature search within the main available medical literature databases was performed for each of the following four areas identified: clinical prediction of survival (CPS), biologic factors, clinical signs and symptoms and psychosocial variables, and prognostic scores. Only studies on patients with advanced cancer and survival < or = 90 days were included.
A total of 38 studies were evaluated. Level A evidence-based recommendations of prognostic correlation could be formulated for CPS (albeit with a series of limitations of which clinicians must be aware) and prognostic scores. Recommendations on the use of other prognostic factors, such as performance status, symptoms associated with cancer anorexia-cachexia syndrome (weight loss, anorexia, dysphagia, and xerostomia), dyspnea, delirium, and some biologic factors (leukocytosis, lymphocytopenia, and C-reactive protein), reached level B.
Prognostication of life expectancy is a significant clinical commitment for clinicians involved in oncology and palliative care. More accurate prognostication is feasible and can be achieved by combining clinical experience and evidence from the literature. Using and communicating prognostic information should be part of a multidisciplinary palliative care approach.
Mots-clé
Biomarkers/analysis, Evidence-Based Medicine, Humans, Life Expectancy, Mental Health, Neoplasms/complications, Neoplasms/pathology, Neoplasms/therapy, Practice Guidelines as Topic, Prognosis, Terminal Care
Pubmed
Web of science
Création de la notice
13/02/2019 16:03
Dernière modification de la notice
20/08/2019 16:42
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