Celecoxib after the onset of reperfusion reduces apoptosis in the amygdala.

Détails

ID Serval
serval:BIB_C6FB8824C64E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Celecoxib after the onset of reperfusion reduces apoptosis in the amygdala.
Périodique
Apoptosis
Auteur(s)
Kaloustian S., Wann B.P., Bah T.M., Falcao S., Dufort A.M., Ryvlin P., Godbout R., Rousseau G.
ISSN
1360-8185 (Print)
ISSN-L
1360-8185
Statut éditorial
Publié
Date de publication
11/2007
Peer-reviewed
Oui
Volume
12
Numéro
11
Pages
1945-1951
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Reperfused myocardial infarction induces an inflammatory response that is responsible for local and systemic alterations. Among these, apoptosis observed in the amygdala following myocardial infarction has been pointed out as a consequence of such an inflammatory process. We hypothesized that inhibition of the inducible inflammatory enzyme Cox-2 during the reperfusion period may attenuate the apoptotic process in the amygdala. Anaesthetized rats were subjected to left anterior descending coronary artery occlusion for 40 min, followed by reperfusion. The Cox-2 antagonist Celecoxib (3 mg/kg i.p.) was administered 10 min after the onset of the reperfusion period. After 72 h of reperfusion, infarct size was determined and the lateral and medial amygdala were dissected from the brain. Infarct size was similar between untreated and Celecoxib-treated animals (40-45% of the area at risk). Cox-2 expression was significantly reduced in both parts of the amygdala in the Celecoxib group. Apoptosis regression was observed in the amygdala of the Celecoxib group as shown by decreased number of TUNEL positive cells and by decreased of caspase-3 activation. Bax/Bcl-2 ratio was not significantly altered by Celecoxib while Akt activation was increased in the lateral amygdala but not in the medial amygdala. This data indicates that inhibition of Cox-2 by Celecoxib is associated with regression of apoptosis in the amygdala following myocardial infarction.
Mots-clé
Amygdala/cytology, Amygdala/drug effects, Animals, Apoptosis/drug effects, Celecoxib, Cyclooxygenase Inhibitors/pharmacology, Myocardial Reperfusion, Myocardial Reperfusion Injury/drug therapy, Myocardial Reperfusion Injury/prevention & control, Pyrazoles/pharmacology, Rats, Rats, Sprague-Dawley, Sulfonamides/pharmacology
Pubmed
Web of science
Création de la notice
29/11/2018 13:36
Dernière modification de la notice
20/08/2019 16:42
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