Genetic difference in HLA-DR phenotypes between coeliac disease and transitory gluten intolerance.

Détails

ID Serval
serval:BIB_C6DD04B1FFBA
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Genetic difference in HLA-DR phenotypes between coeliac disease and transitory gluten intolerance.
Périodique
Archives of Disease in Childhood
Auteur(s)
Meuli R., Pichler W.J., Gaze H., Lentze M.J.
ISSN
1468-2044
Statut éditorial
Publié
Date de publication
01/1995
Peer-reviewed
Oui
Volume
72
Numéro
1
Pages
29-32
Langue
anglais
Notes
Journal Article --- Old month value: Jan
Résumé
Genetic differences in HLA phenotypes were studied in coeliac disease to investigate why some patients do not react with mucosal damage after gluten challenge. Forty five children with coeliac disease and 16 with transitory gluten intolerance were typed; 76 subjects served as controls. HLA phenotypes in children with coeliac disease had significantly higher proportions of DR3/X and DR5/7 than controls (48.8% v 11.8% and 26.7% v 5.3%). Children with transitory gluten intolerance had lower DR3/X (43.8%) than children with coeliac disease and there were no DR5/7 phenotypes. Further analysis of similarly well defined cases might show whether genetic differences in the DR3/X and DR5/7 phenotypes can serve as a marker for the permanence of gluten intolerance.
Mots-clé
Adolescent, Adult, Celiac Disease/genetics, Child, Female, Gene Frequency, Glutens/adverse effects, Glutens/diagnostic use, HLA-DR Antigens/genetics, HLA-DR3 Antigen/genetics, HLA-DR5 Antigen/genetics, HLA-DR7 Antigen/genetics, Humans, Male, Phenotype
Pubmed
Web of science
Open Access
Oui
Création de la notice
08/04/2008 15:47
Dernière modification de la notice
20/08/2019 16:42
Données d'usage