Metabolic and epigenetic regulation of T-cell exhaustion.

Détails

ID Serval
serval:BIB_C6CC159592FD
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Metabolic and epigenetic regulation of T-cell exhaustion.
Périodique
Nature metabolism
Auteur(s)
Franco F., Jaccard A., Romero P., Yu Y.R., Ho P.C.
ISSN
2522-5812 (Electronic)
ISSN-L
2522-5812
Statut éditorial
Publié
Date de publication
10/2020
Peer-reviewed
Oui
Volume
2
Numéro
10
Pages
1001-1012
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Current immunotherapies yield remarkable clinical outcomes by boosting the power of host immunity in cancer cell elimination and viral clearance. However, after prolonged antigen exposure, CD8 <sup>+</sup> T cells differentiate into a special differentiation state known as T-cell exhaustion, which poses one of the major hurdles to antiviral and antitumor immunity during chronic viral infection and tumour development. Growing evidence indicates that exhausted T cells undergo metabolic insufficiency with altered signalling cascades and epigenetic landscapes, which dampen effector immunity and cause poor responsiveness to immune-checkpoint-blockade therapies. How metabolic stress affects T-cell exhaustion remains unclear; therefore, in this Review, we summarize current knowledge of how T-cell exhaustion occurs, and discuss how metabolic insufficiency and prolonged stress responses may affect signalling cascades and epigenetic reprogramming, thus locking T cells into an exhausted state via specialized differentiation programming.
Pubmed
Web of science
Création de la notice
28/09/2020 9:34
Dernière modification de la notice
11/11/2020 7:24
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