Iloprost improves running performance at 5,000 m in Han but not in Tibetans

Détails

Ressource 1Télécharger: han vs tibetan iloprost.pdf (572.18 [Ko])
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_C6C4BEB2A895
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Iloprost improves running performance at 5,000 m in Han but not in Tibetans
Périodique
Current Issues in Sport Science
Auteur(s)
Kayser B., Fan J.-L., Nan L., Bang W.L., Wu B., Wu T.
ISSN
2414-6641 (Online)
Statut éditorial
Publié
Date de publication
12/03/2019
Peer-reviewed
Oui
Volume
4
Pages
NA
Langue
anglais
Résumé
Background: Tibetans lose less aerobic exercise capacity in hypoxia compared to lowland Han. We tested if inhalation of iloprost (to counter hypoxic pulmonary vasoconstriction) and furosemide (to decrease afferent vagal traffic from pulmonary receptors) improve performance in hypoxia in Han compared to Tibetans. Methods: 8 Tibetans and 8 Han, living at 2,260 m, did incremental uphill treadmill running to exhaustion at ambient pressure on day 1, followed by three runs at 5,000 m (hypobaric chamber) after inhalation of iloprost (ILO), furosemide (FUR) or placebo (PLA), on different days in a counter-balanced order. Results: In Han the performance decrement from 2,260 m to 5,000 m was greater than in Tibetans (p<0.05). In Han iloprost improved performance at 5,000 m compared to placebo (p<0.05 vs. PLA); furosemide had no effects. In Tibetans there were no treatment effects. Peripheral O2 saturations at peak exercise at 5,000 m, were higher by ~8 % in the Tibetans (p<0.05 vs. Han). Maximum heart rate was lowered by 13±6 bpm in Han at 5,000 m regardless of treatment compared to 2,260 m (p<0.05). Tibetans reached similar maximum heart rates ~200 bpm at 5,000 m and 2,260 m, independent of treatment. Conclusions: The blunting of the exercise impairment in severe hypoxia in Han during maximal exercise after inhalation of iloprost suggests that hypoxic pulmonary vasoconstriction and right ventricular function are potential performance limiting factors in Han in hypoxia.
Mots-clé
hypoxia, altitude, Tibet, exercise, heart, lung, cardiac, pulmonary, right ventricle, heart rate, performance
Création de la notice
12/03/2019 16:12
Dernière modification de la notice
20/08/2019 16:42
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