Comprehensive genomic characterization of squamous cell lung cancers.
Détails
ID Serval
serval:BIB_C6A905D4766B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Comprehensive genomic characterization of squamous cell lung cancers.
Périodique
Nature
Collaborateur⸱rice⸱s
Cancer Genome Atlas Research Network
Contributeur⸱rice⸱s
Hammerman P.S., Lawrence M.S., Voet D., Jing R., Cibulskis K., Sivachenko A., Stojanov P., McKenna A., Lander E.S., Gabriel S., Getz G., Sougnez C., Imielinski M., Helman E., Hernandez B., Pho N.H., Meyerson M., Chu A., Chun H.J., Mungall A.J., Pleasance E., Robertson A., Sipahimalani P., Stoll D., Balasundaram M., Birol I., Butterfield Y.S., Chuah E., Coope R.J., Corbett R., Dhalla N., Guin R., He A., Hirst C., Hirst M., Holt R.A., Lee D., Li H.I., Mayo M., Moore R.A., Mungall K., Nip K.M., Olshen A., Schein J.E., Slobodan J.R., Tam A., Thiessen N., Varhol R., Zeng T., Zhao Y., Jones S.J., Marra M.A., Saksena G., Cherniack A.D., Schumacher S.E., Tabak B., Carter S.L., Pho N.H., Nguyen H., Onofrio R.C., Crenshaw A., Ardlie K., Beroukhim R., Winckler W., Hammerman P.S., Getz G., Meyerson M., Protopopov A., Zhang J., Hadjipanayis A., Lee S., Xi R., Yang L., Ren X., Zhang H., Shukla S., Chen P.C., Haseley P., Lee E., Chin L., Park P.J., Kucherlapati R., Socci N.D., Liang Y., Schultz N., Borsu L., Lash A.E., Viale A., Sander C., Ladanyi M., Auman T., Hoadley K.A., Wilkerson M.D., Shi Y., Liquori C., Meng S., Li L., Turman Y.J., Topal M.D., Tan D., Waring S., Buda E., Walsh J., Jones C.D., Mieczkowski P.A., Singh D., Wu J., Gulabani A., Dolina P., Bodenheimer T., Hoyle A.P., Simons J.V., Soloway M.G., Mose L.E., Jefferys S.R., Balu S., O'Connor B.D., Prins J.F., Liu J., Chiang D.Y., Hayes D., Perou C.M., Cope L., Danilova L., Weisenberger D.J., Maglinte D.T., Pan F., Van Den Berg D.J., Triche T., Herman J.G., Baylin S.B., Laird P.W., Getz G., Noble M., Voet D., Saksena G., Gehlenborg N., DiCara D., Zhang J., Zhang H., Wu C.J., Liu S.Y., Lawrence M.S., Zou L., Sivachenko A., Lin P., Stojanov P., Jing R., Cho J., Nazaire M.D., Robinson J., Thorvaldsdottir H., Mesirov J., Park P.J., Chin L., Schultz N., Sinha R., Ciriello G., Cerami E., Gross B., Jacobsen A., Gao J., Aksoy B., Weinhold N., Ramirez R., Taylor B.S., Antipin Y., Reva B., Shen R., Mo Q., Seshan V., Paik P.K., Ladanyi M., Sander C., Akbani R., Zhang N., Broom B.M., Casasent T., Unruh A., Wakefield C., Cason R., Baggerly K.A., Weinstein J.N., Haussler D., Benz C.C., Stuart J.M., Zhu J., Szeto C., Scott G.K., Yau C., Ng S., Goldstein T., Waltman P., Sokolov A., Ellrott K., Collisson E.A., Zerbino D., Wilks C., Ma S., Craft B., Wilkerson M.D., Auman J., Hoadley K.A., Du Y., Cabanski C., Walter V., Singh D., Wu J., Gulabani A., Bodenheimer T., Hoyle A.P., Simons J.V., Soloway M.G., Mose L.E., Jefferys S.R., Balu S., Marron J., Liu Y., Wang K., Liu J., Prins J.F., Hayes D., Perou C.M., Creighton C.J., Zhang Y., Travis W.D., Rekhtman N., Yi J., Aubry M.C., Cheney R., Dacic S., Flieder D., Funkhouser W., Illei P., Myers J., Tsao M.S., Penny R., Mallery D., Shelton T., Hatfield M., Morris S., Yena P., Shelton C., Sherman M., Paulauskis J., Meyerson M., Baylin S.B., Govindan R., Akbani R., Azodo I., Beer D., Bose R., Byers L.A., Carbone D., Chang L.W., Chiang D., Chu A., Chun E., Collisson E., Cope L., Creighton C.J., Danilova L., Ding L., Getz G., Hammerman P.S., Hayes D., Hernandez B., Herman J.G., Heymach J., Ida C., Imielinski M., Johnson B., Jurisica I., Kaufman J., Kosari F., Kucherlapati R., Kwiatkowski D., Ladanyi M., Lawrence M.S., Maher C.A., Mungall A., Ng S., Pao W., Peifer M., Penny R., Robertson G., Rusch V., Sander C., Schultz N., Shen R., Siegfried J., Sinha R., Sivachenko A., Sougnez C., Stoll D., Stuart J., Thomas R.K., Tomaszek S., Tsao M.S., Travis W.D., Vaske C., Weinstein J.N., Weisenberger D., Wheeler D., Wigle D.A., Wilkerson M.D., Wilks C., Yang P., Zhang J.J., Jensen M.A., Sfeir R., Kahn A.B., Chu A.L., Kothiyal P., Wang Z., Snyder E.E., Pontius J., Pihl T.D., Ayala B., Backus M., Walton J., Baboud J., Berton D.L., Nicholls M.C., Srinivasan D., Raman R., Girshik S., Kigonya P.A., Alonso S., Sanbhadti R.N., Barletta S.P., Greene J.M., Pot D.A., Tsao M.S., Bandarchi-Chamkhaleh B., Boyd J., Weaver J., Wigle D.A., Azodo I.A., Tomaszek S.C., Aubry M.C., Ida C.M., Yang P., Kosari F., Brock M.V., Rodgers K., Rutledge M., Brown T., Lee B., Shin J., Trusty D., Dhir R., Siegfried J.M., Potapova O., Fedosenko K.V., Nemirovich-Danchenko E., Rusch V., Zakowski M., Iacocca M.V., Brown J., Rabeno B., Czerwinski C., Petrelli N., Fan Z., Todaro N., Eckman J., Myers J., Rathmell W., Thorne L.B., Huang M., Boice L., Hill A., Penny R., Mallery D., Curley E., Shelton C., Yena P., Morrison C., Gaudioso C., Bartlett J.M., Kodeeswaran S., Zanke B., Sekhon H., David K., Juhl H., Van Le X., Kohl B., Thorp R., Nguyen V.T., Nguyen V.B., Sussman H., Phu B.D., Hajek R., Nguyen P.H., Khan K.Z., Muley T., Shaw K.R., Sheth M., Yang L., Buetow K., Davidsen T., Demchok J.A., Eley G., Ferguson M., Dillon L.A., Schaefer C., Guyer M.S., Ozenberger B.A., Palchik J.D., Peterson J., Sofia H.J., Thomson E.
ISSN
1476-4687 (Electronic)
ISSN-L
0028-0836
Statut éditorial
Publié
Date de publication
27/09/2012
Peer-reviewed
Oui
Volume
489
Numéro
7417
Pages
519-525
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural
Publication Status: ppublish
Publication Status: ppublish
Résumé
Lung squamous cell carcinoma is a common type of lung cancer, causing approximately 400,000 deaths per year worldwide. Genomic alterations in squamous cell lung cancers have not been comprehensively characterized, and no molecularly targeted agents have been specifically developed for its treatment. As part of The Cancer Genome Atlas, here we profile 178 lung squamous cell carcinomas to provide a comprehensive landscape of genomic and epigenomic alterations. We show that the tumour type is characterized by complex genomic alterations, with a mean of 360 exonic mutations, 165 genomic rearrangements, and 323 segments of copy number alteration per tumour. We find statistically recurrent mutations in 11 genes, including mutation of TP53 in nearly all specimens. Previously unreported loss-of-function mutations are seen in the HLA-A class I major histocompatibility gene. Significantly altered pathways included NFE2L2 and KEAP1 in 34%, squamous differentiation genes in 44%, phosphatidylinositol-3-OH kinase pathway genes in 47%, and CDKN2A and RB1 in 72% of tumours. We identified a potential therapeutic target in most tumours, offering new avenues of investigation for the treatment of squamous cell lung cancers.
Mots-clé
Adenocarcinoma/drug therapy, Adenocarcinoma/genetics, Adenocarcinoma/metabolism, Carcinoma, Squamous Cell/drug therapy, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/metabolism, DNA Mutational Analysis, Gene Deletion, Gene Expression Profiling, Gene Expression Regulation, Neoplastic, Genes, p16, Genes, p53/genetics, Genome, Human/genetics, Genomics, Humans, Lung Neoplasms/drug therapy, Lung Neoplasms/genetics, Lung Neoplasms/metabolism, Molecular Targeted Therapy, Mutation/genetics, Mutation Rate, Phosphatidylinositol 3-Kinases/metabolism, Signal Transduction/genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
06/07/2018 12:02
Dernière modification de la notice
21/08/2019 6:34
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