The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation

Détails

ID Serval
serval:BIB_C67686199F0E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The Yaa mutation induces the development of autoimmunity in mice heterozygous for the gld (generalized lymphadenopathy disease) mutation
Périodique
Cellular Immunology
Auteur(s)
Rosenblatt  N., Hartmann  K. U., Loor  F.
ISSN
0008-8749 (Print)
Statut éditorial
Publié
Date de publication
07/1994
Volume
156
Numéro
2
Pages
519-28
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
Mice homozygous for either the generalized lymphoproliferative disease (gld) or the lymphoproliferation (lpr) nonallelic mutations develop similar syndromes combining systemic autoimmunity and lymphoproliferative disease. Though essentially recessive, the lpr and gld mutations may be expressed in the heterozygous state: [lpr/+] mice displayed a mild "lpr-like" autoimmunity, and the [lprcg/+ gld/+] mice developed a "gld-like" disorder, showing interactions of the gld gene product with the nonallelic lprcg product. The Y-chromosome-linked autoimmune accelerator (Yaa) mutation being an autoimmunity accelerator, its association with an heterozygous gld gene might also bring a gld-like syndrome. The [gld/+ Yaa] mice were shown here to develop autoimmunity and splenomegaly like [gld/gld] mice, but without their typical lymphadenopathy. Furthermore, the [gld/+ Yaa] splenomegaly was not due to the expansion of the unusual Thy1+ B220+ T-cell subset typical of the gld syndrome, but rather to a polyclonal expansion of the major lymphoid cell subsets. Thus, the syndrome shown by [gld/+ Yaa] mice was not a gld-like syndrome. This suggests that the interactions of the gld gene product with the Yaa product and with the lprcg product must be different.
Mots-clé
Animals Antibodies, Antinuclear/blood Autoimmune Diseases/complications/*genetics/immunology Female Heterozygote Immunoglobulin Isotypes/blood Lymph Nodes/immunology/pathology Lymphoproliferative Disorders/complications/*genetics/immunology Male Mice Mice, Inbred C57BL Mice, Mutant Strains *Mutation Phenotype Spleen/immunology/pathology
Pubmed
Web of science
Création de la notice
25/01/2008 8:48
Dernière modification de la notice
20/08/2019 15:41
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