Relation between high-sensitivity C-reactive protein and cardiovascular and renal markers in a middle-income country in the African region.

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Ressource 1Télécharger: BIB_C672C818629A.P001.pdf (180.78 [Ko])
Etat: Public
Version: Author's accepted manuscript
ID Serval
serval:BIB_C672C818629A
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Relation between high-sensitivity C-reactive protein and cardiovascular and renal markers in a middle-income country in the African region.
Périodique
International Journal of Cardiology
Auteur⸱e⸱s
Rossi Isabelle Anne, Bochud Murielle, Viswanathan Bharathi, Riesen Walter, Bovet Pascal
ISSN
1874-1754 (Electronic)
ISSN-L
0167-5273
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
156
Numéro
2
Pages
203-208
Langue
anglais
Résumé
BACKGROUND: High-sensitivity C-reactive protein (hs-CRP) is associated with several cardiovascular risk factors (CVRF) and with renal function markers. However, these associations have not been examined in populations in the African region. We analyzed the distribution of hs-CRP and the relationship with a broad set of CVRF, renal markers and carotid intima-media thickness (IMT), in the Seychelles (African region). METHODS: We conducted a survey in the population aged 25-64years (n=1255, participation rate: 80.2%). Analyses were restricted to persons of predominantly African descent (n=1011). RESULTS: Mean and median hs-CRP serum concentrations (mg/l) were 3.1 (SD 7.6) and 1.4 (IQR 0.7-2.9) in men and 4.5 (SD 6.7) and 2.2 (IQR 1.0-5.4) in women (p<0.001 for difference between men and women). hs-CRP was significantly associated with several conventional CVRF, and particularly strongly with markers of adiposity. With regards to renal markers, hs-CRP was strongly associated with cystatin C and with microalbuminuria but not with creatinine. hs-CRP was not associated with IMT. CONCLUSIONS: Serum concentration of hs-CRP was significantly associated with sex, several CVRF and selected renal function markers, which extends similar findings in Europe and in North America to a population in the African region. These findings can contribute to guide recommendations for the use of hs-CRP in clinical practice in the region.
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/10/2011 17:01
Dernière modification de la notice
20/08/2019 16:41
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