Nutritional papers in ICU patients: what lies between the lines?

Détails

ID Serval
serval:BIB_C67038727C6B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Nutritional papers in ICU patients: what lies between the lines?
Périodique
Intensive Care Medicine
Auteur(s)
Preiser  J. C., Chiolero  R., Wernerman  J.
ISSN
0342-4642 (Print)
Statut éditorial
Publié
Date de publication
02/2003
Volume
29
Numéro
2
Pages
156-166
Notes
Journal Article Review --- Old month value: Feb
Résumé
The abundance of literature related to nutritional support reflects its recently recognised role in preventing metabolic complications and gut dysfunction during critical illness. However, some published studies lack relevance to critically ill patients, as a result of the selection of subjects and outcome variables, or flaws in the study design, as well as in the type, composition, timing, route of administration and amount of nutritional support given. This review will highlight these confounding factors by describing two imaginary (but typical) clinical trials and by analysing some studies published. The point at issue is that basic quality requirements, such as the formulation of a prospective hypothesis and the delineation of the effects of the reference treatment, are often lacking in many studies published. Data analysis was often found to be biased by the absence of statistical power calculation and intention-to-treat analysis. Globally, studies designed to assess the effects of nutritional support on the outcome of critically ill patients, rarely fulfil basic quality requirements and should therefore be interpreted cautiously. We suggest simple strategies or study design that will allow important questions to be answered by future clinical trials.
Mots-clé
Clinical Trials/*standards Cost-Benefit Analysis Critical Illness/mortality/*therapy Data Interpretation, Statistical Energy Metabolism Guidelines Hospital Mortality Humans Information Storage and Retrieval Intensive Care/economics/*methods/standards Length of Stay Medline Nutritional Requirements Nutritional Support/economics/*methods/standards Publishing Research Design/*standards Safety Selection Bias Time Factors Treatment Outcome
Pubmed
Web of science
Création de la notice
24/01/2008 16:52
Dernière modification de la notice
20/08/2019 15:41
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