T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy.

Détails

Ressource 1Télécharger: BIB_C6457A27B855.P001.pdf (708.82 [Ko])
Etat: Public
Version: de l'auteur
ID Serval
serval:BIB_C6457A27B855
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
T-cell and NK-cell infiltration into solid tumors: a key limiting factor for efficacious cancer immunotherapy.
Périodique
Cancer Discovery
Auteur(s)
Melero I., Rouzaut A., Motz G.T., Coukos G.
ISSN
2159-8290 (Electronic)
ISSN-L
2159-8274
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
4
Numéro
5
Pages
522-526
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't Publication Status: ppublish PDF : Views
Résumé
Cancer immunotherapy has great promise, but is limited by diverse mechanisms used by tumors to prevent sustained antitumor immune responses. Tumors disrupt antigen presentation, T/NK-cell activation, and T/NK-cell homing through soluble and cell-surface mediators, the vasculature, and immunosuppressive cells such as myeloid-derived suppressor cells and regulatory T cells. However, many molecular mechanisms preventing the efficacy of antitumor immunity have been identified and can be disrupted by combination immunotherapy. Here, we examine immunosuppressive mechanisms exploited by tumors and provide insights into the therapies under development to overcome them, focusing on lymphocyte traffic.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2014 14:09
Dernière modification de la notice
20/08/2019 15:41
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