Microglia control small vessel calcification via TREM2.

Détails

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Etat: Public
Version: Final published version
Licence: CC BY-NC 4.0
ID Serval
serval:BIB_C64510F66413
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Microglia control small vessel calcification via TREM2.
Périodique
Science advances
Auteur⸱e⸱s
Zarb Y., Sridhar S., Nassiri S., Utz S.G., Schaffenrath J., Maheshwari U., Rushing E.J., Nilsson KPR, Delorenzi M., Colonna M., Greter M., Keller A.
ISSN
2375-2548 (Electronic)
ISSN-L
2375-2548
Statut éditorial
Publié
Date de publication
02/2021
Peer-reviewed
Oui
Volume
7
Numéro
9
Pages
135-145
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Résumé
Microglia participate in central nervous system (CNS) development and homeostasis and are often implicated in modulating disease processes. However, less is known about the role of microglia in the biology of the neurovascular unit (NVU). In particular, data are scant on whether microglia are involved in CNS vascular pathology. In this study, we use a mouse model of primary familial brain calcification, Pdgfb <sup>ret/ret</sup> , to investigate the role of microglia in calcification of the NVU. We report that microglia enclosing vessel calcifications, coined calcification-associated microglia, display a distinct activation phenotype. Pharmacological ablation of microglia with the CSF1R inhibitor PLX5622 leads to aggravated vessel calcification. Mechanistically, we show that microglia require functional TREM2 for controlling vascular calcification. Our results demonstrate that microglial activity in the setting of pathological vascular calcification is beneficial. In addition, we identify a previously unrecognized function of microglia in halting the expansion of vascular calcification.
Mots-clé
Adult, Diet, Diving, Humans, Male, Military Personnel, Naval Medicine, Nutritional Status, United States
Pubmed
Web of science
Open Access
Oui
Création de la notice
09/03/2021 13:36
Dernière modification de la notice
12/01/2022 7:13
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