Drosophila germ-line modulation of insulin signaling and lifespan.

Détails

ID Serval
serval:BIB_C635709629BD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Drosophila germ-line modulation of insulin signaling and lifespan.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur⸱e⸱s
Flatt T., Min K.J., D'Alterio C., Villa-Cuesta E., Cumbers J., Lehmann R., Jones D.L., Tatar M.
ISSN
1091-6490 (Electronic)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
105
Numéro
17
Pages
6368-6373
Langue
anglais
Résumé
Ablation of germ-line precursor cells in Caenorhabditis elegans extends lifespan by activating DAF-16, a forkhead transcription factor (FOXO) repressed by insulin/insulin-like growth factor (IGF) signaling (IIS). Signals from the gonad might thus regulate whole-organism aging by modulating IIS. To date, the details of this systemic regulation of aging by the reproductive system are not understood, and it is unknown whether such effects are evolutionarily conserved. Here we report that eliminating germ cells (GCs) in Drosophila melanogaster increases lifespan and modulates insulin signaling. Long-lived germ-line-less flies show increased production of Drosophila insulin-like peptides (dilps) and hypoglycemia but simultaneously exhibit several characteristics of IIS impedance, as indicated by up-regulation of the Drosophila FOXO (dFOXO) target genes 4E-BP and l (2)efl and the insulin/IGF-binding protein IMP-L2. These results suggest that signals from the gonad regulate lifespan and modulate insulin sensitivity in the fly and that the gonadal regulation of aging is evolutionarily conserved.
Mots-clé
Animals, Drosophila Proteins/genetics, Drosophila Proteins/metabolism, Drosophila melanogaster/genetics, Drosophila melanogaster/metabolism, Female, Gene Expression Regulation, Genes, Insect, Germ Cells/cytology, Germ Cells/metabolism, Insulin/metabolism, Longevity, Male, Ovary/cytology, RNA, Messenger/genetics, RNA, Messenger/metabolism, Signal Transduction, Testis/cytology
Pubmed
Web of science
Open Access
Oui
Création de la notice
28/01/2013 12:27
Dernière modification de la notice
20/08/2019 15:41
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